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9999: test

tis is a test

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CHM-0599: Efficient synthesis of a polyacene monomer

An efficient method has been developed for synthesizing a monomer that, when polymerized, is anticipated to exhibit directional (i.e. anisotropic) conductivity substantial (possibly immense) mechanical strength, and possibly even room temperature superconductivity. These polymers are named polyacenes. Possible applications include VLSI interconnects, long distance transmission lines, MRI/NMR, RF, and microwave filters, among others.

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CHM-0620: Variable lenslet array

Measuring wave front distortions is widely practiced in optics and is essential for adaptive optics, optical shop testing, wafer measurements and other fields. Conventional wave front sensors have difficulty measuring wave fronts under severe conditions such as low light level, fast scale variations, large aberrations, wide dynamic range, both lateral and in depth and discontinuities in the wave front. This unique invention uses a variable lenslet array to sense wave fronts even under these severe conditions and meets this need in a simple and effective way without any mechanical motion.

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CHM-0676: Determination of thin film topography

Thin film metrology is extremely important in QA, inspection and process control procedures (e.g., in the semiconductors industry). Our three-beam interferometry compact system allows a low-cost, non-destructive, highly accurate measurement of thin film thickness and topography, with depths as thin as 2nm and without any limitation on substrate opacity.

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CHM-0708: Negative fullerene ion beams generation - method and apparatus

The production of neutral and negative molecular ion beams is of considerable importance in diverse areas of physics, in the production of nano-electro-mechanical and nanophotonics systems, synthesis of new materials, electric propulsion devices, fundamental science areas as surface chemistry and catalysis, organic chemistry, and biology and other fields. This system ionizes neutral C60 fullerenes as they pass through a ceramic capillary giving a very pure, bright and focused ion beam with a narrow energy spread.

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CHM-0918: Low-friction molecular rotary motors

Nanomotors are becoming increasingly important as nano-mechanical systems are continuing to develop. Molecular rotors can be attached to a solid support and used in a variety of applications such as energy converters (motors) biochips and biosensors. The most important traits for a molecular rotary motor are unidirectional motion and high speed rotation with low friction. This nanomotor is able to achieve high-speed motion with minimal friction minimizing dissipation of energy by creating rotation with a very low energy barrier using a rotator-stator couple with repulsive interactions between them. A device of this type is unprecedented in the micro level but has already been applied in the macro scale in maglev suspension systems.

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CHM-0989: Low cost onsite generation of high purity oxygen

Current on-site generators separate oxygen from the air using adsorption. These generators provide insufficient oxygen purity for most applications, in particular when producing high flow rates. Our technology uses a ceramic membrane that allows for fast generation of high quality oxygen at practically 100% concentration under any desired flow rate. This invention can be applied to several industries and applications such as: medicine, chemical manufacture, coal gasification, oxyfuel combustion, fish farms, aircraft, gear for trauma medicine, scuba or other breathing apparatuses.

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CHM-1033: Method for identifying electrophiles and nucleophiles in a sample

This technology offers a low-cost, continuous and informative way of detecting electrophiles or nucleophiles in solution and in the gas phase. This has numerous applications like in early warning systems for nerve and mustard gas or for worker safety systems in various chemical industries. This technology works similar to the olfactory system of living organisms by using numerous chemosensors that identify electrophilic and nucleophilic molecules by chemically reacting with them. The technology was demonstrated using electrical (field effect transistors) as well as through optical (luminescence) means.

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CHM-1034: Optical tweezers

New devices and technologies rely on “micro pumps” to transport fluids. Our technology allows beams of light to manipulate the local density of particles suspended in liquids or gases. It can be used to control the physical and chemical properties of the fluid, and to manipulate particles of various sizes, ranging from micrometers to nanometers. At the micro and nano-scale, the optical pump has a higher efficiency as compared to rotating mechanical pumps, while having no moving parts. This technology has applications in nanotechnology, micro-chemistry, holography, and many more.

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CHM-1065: Production of barium titanate layer

Barium titanate (BaTiO3) is one of the most important ceramic materials used in electronics. As an intrinsic ferroelectric material it can be utilized for various applications like multilayer capacitors, grain boundary capacitors, low-temperature sensors and thermistors. There is a growing need for efficient methods of producing barium titanate layers, particularly if they are thin and crack-free. This method allows for the preparation of thin, whole layers even in complex shapes without the use of extremely toxic solutions currently in use in other methods.

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CHM-1084: Silicon air batteries

New metal-air batteries based on a silicon (Si) anode yield a capacity four times that of conventional Zn-air batteries. We have solved the low conductivity problem of Si by using highly doped and metalized silicon. The novelty in this method is the use of a semiconductor such as Si for generation of energy. It is accomplished by utilizing silica as the reaction product with oxygen and a particular ionic liquid as electrolyte.

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CHM-1097: Microstructure control of ceramic matrix nanocomposites

A method facilitating a way to obtain ceramic nanocomposites via a safe and very low cost process yielding ceramics with improved strengths and with a significantly improved Weibull modulus. The material also shows remarkable wear properties. Example applications include ceramic cutting tools, ballistic armor, car brake pads, parts for textile fabrication, advanced ceramics for a multitude of applications in the semiconductor manufacturing industry (e.g., capillaries for wire-bonding), and electronic components.

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CHM-1155: Organic transistors

Organic electronic components benefit from low-cost and large-area fabrication and flexible and unconventional substrate amenability. Organic field-effect transistors (OFETs) are expected to be integrated in a variety of applications including RFID tags, flexible active matrix displays, and bio-compatible sensors arrays. However, the inherent low mobility of organic semiconductors (OSCs) requires high operating voltage and high power consumption which is less than ideal for most applications. This innovative design offers low-cost, high performance, organic switching devices capable of delivering high current densities. Equally important, the unique vertical architecture lends itself to functionalization to light-emitting purposes; such combination offers the exciting possibility of joining light emitting and logic elements in pixels into one device, lowering production costs, freeing up “dark” pixel areas, and increasing operational lifetime.

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CHM-1159: Calixurenes - novel binding molecules

There are four main known families of macrocyclic host molecules based on specific host-guest reversible binding that are employed in a wide range of applications in chemistry, biology, the food industry, electronics or printing. Despite this, for more than a decade, no new family of macrocyclic host molecules has been discovered and the known macrocycles are usually limited to specific applications according to their chemical nature and binding properties. These new molecules called Calixurenes are the first binding macrocycles that contain thiourea combined with aromatic fragments and phenolic functions. This unique combination of functional groups in the same molecule is expected to produce unprecedented binding strength with high selectivity to almost any metal in any oxidation state as well as binding properties expected to be independent of the environment.

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CHM-1173: Direct and nondestructive chemical analysis of solid samples

Chemical analysis is usually performed in solutions or in the gas phase, while direct detection of solids is much more difficult. This breakthrough spectroscopic method utilizing laser multi-photon ionization (MPI) is performed under ambient conditions and is suitable for direct analysis of solid materials providing rich spectral features that can be used for compound identification. This technology has applications in industrial process control (e.g., semiconductor wafers), in quality assurance (e.g., pharmaceuticals), in forensic applications (e.g., explosives, narcotics) and in several environmental monitoring applications. This novel method has been successfully laboratory-demonstrated and was used for the detection of various organic compounds including explosives, narcotic drugs and polycyclic aromatics.

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CHM-1236: Liquid droplet elastomer

A liquid droplet elastomer is a novel, liquid-filled rubbery polymer which combines an elastomer with individually encapsulated micron-scale droplets of liquid or gel. This low-cost and scalable process based on Pickering emulsions and polyHIPEs produces liquid-filled capsules with capsule walls capable of withstanding repeated mechanical and thermal stresses without failure due to the high level of liquid retention. This innovative technology is highly customizable and lends itself to a wide range of applications including thermal and mechanical insulation, antibacterial medical equipment and fire-resistant cladding.

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CHM-1337: Shape-memory foams

Shape memory foams are lightweight materials that can undergo significant reversible and reproducible changes in their dimensions when heated above a specific stimulus temperature. The shape is then ‘locked’ in when the material is cooled. These materials can have biomedical applications, can be incorporated into mechanical systems and can be used to create ‘healing’ materials for spacecraft, automobiles or watercraft. This invention is a specific class of shape memory foam that can be customized for a wide range of stimulus temperatures and mechanical properties through variations in the chemical composition of the material.

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CHM-1368: Diamond coating

The industrial use of diamond films for coating various substrates increases constantly due to diamond’s exceptional optical, mechanical, thermal and electrical properties. However, diamond coatings exhibit poor adhesion when deposited onto metallic substrates such as steel and tungsten carbide. The latter is used for industrial cutting tools and there is a great need for a durable diamond coating on these components to enhance their capability and lifetime. This invention uses an interlayer that acts as a diffusion barrier that adheres well to the metallic substrate and acts as a substrate for the diamond coating creating a coating with superior properties. 

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CHM-1375: Grignard reagent

Metal-organic Grignard reagents are widely used throughout the fine chemical and pharmaceutical industries and are commonly combined with an ether solvent. This combination can make it difficult to control the reaction rate and ether is a volatile compound that must be stored and transported with great care to prevent accidents or the formation of explosive compounds. This invention is for a method for synthesizing Grignard reagents and then performing the reaction with the reagents in the same reactor vessel. This eliminates the need for the use of hazardous ethers and increases control over the reaction increasing the reliability, cost-efficiency and safety of the chemical manufacture.

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CHM-1396: Low-cost fabrication of vicinal and stepped surfaces for enhanced catalysis

Despite their proven catalytic prowess, use of vicinal surfaces as catalysis enhancers has yet to take hold in the industry due to high production costs. Conventional formation of vicinal surfaces is performed on single crystals under high temperatures and ultra-high vacuum, making the manufacturing process expensive and inflexible. Such processes require additional complicated, energy and time-consuming treatments like low-angle miscuts, surface sputtering, and high-vacuum annealing. In contrast, our technology, allows for the formation of vicinal surfaces on various thin polycrystalline materials at almost room temperature and atmospheric pressure without the need for subsequent procedures-greatly increasing the flexibility, efficiency and cost-effectiveness of their manufacture.

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CHM-1399: Preparation and use of alfa-hydrogen substituted nitroxyls as catalysts

The synthesis of ketones and aldehydes is an ubiquitous process in industrial and academic preparation of organic compounds (drugs, fragrances, food additives, etc.). This new and innovative stable nitroxyl compound can be prepared in racemic form in only 5 chemical steps from cheap and environmentally-friendly starting materials. This compound catalyzes oxidation of primary and secondary alcohols to ketones and aldehydes rapidly, efficiently and at room temperature. This compound allows for the synthesis of a wide range of alcohol derivatives without creating byproducts laden with heavy metals.

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CHM-1407: Method for reversible and bistable switching of current in electron field emission

Innovative memory switch devices require reliable bistable conductance properties. It would be desirable if such bistable characteristics were available in robust solid state materials such as diamond, benefiting from outstanding physical properties. Here we report on a bistable current with reversible switching effect from surface transfer doped ultrananocrystalline diamond thin films measured by electron field emission. This switching is manifested by the appearance of huge jumps in the current emission, up to 4 orders of magnitude, occurring at specific extracting electric field values. Persistent hysteresis is exhibited whenever the field is ramped down. We propose that these phenomena are the result of resonant-tunneling through a double barrier junction composed of ta-C-/ Nano Diamond-/ adsorbent-/ vacuum. This finding shows the first electron source material having ultrafast switching with memory effect; this may use for the realization of novel kinds of memory switch devices with unprecedented performance or electron sources with high resolution and fast response.

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CHM-1414: Superomniphobic anti-bacterial and anti-fungal surfaces

One of the most fascinating properties of materials in nature is the superhydrophobic and self-cleaning capabilities of different insects and plant surfaces. Based on these phenomena, bioinspired,”nanoengineered” surfaces (NES) have been produced for a myriad of commercial applications ranging from biomedical applications and electronics to textile and optics. This invention presents a method for the production of superomniphobic (superhydrophobic and superoleophobic) surfaces that also renders the surface anti-bacterial and anti-fungal by preventing biofilm growth. The method to form such surfaces utilizes a simple, versatile and low cost one-step production scheme.

 
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CHM-1420: Cellulose encapsulated dispersions for thermal energy storage

Encapsulation of a material inside of another has almost endless applications that include prolonging the shelf-life of a medicine, vitamin or chemical or causing its slow release, creating ‘self-healing’ materials, energy or thermal storage or insulation, or in automobile, airplane or rocket engine heat exchangers. This novel method for the encapsulation of materials in cellulose shells allowing for the creation of oil-in-water or water-in-oil dispersions without the use of surfactants. These unique green materials can be made with low-cost, non-toxic, inert, recyclable and biodegradable materials.

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CHM-1500: Novel P-dopant for strong and superior surface diamond

This invention presents a new dopant facilitating highly conductive p-type diamond layers (based on transfer doping) that are stable up to at least 350°C. We demonstrated conductance that is over 1 order of magnitude higher than that of diamond surface layers doped by other molecules. Our doping process makes use of standard evaporation deposition which is easy, controllable and tunable. This novel doping makes it an attractive alternative for diamond-based electronic device applications.

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CHM-1536: Quantum dot band gap tuning with amino acids

For many applications in electronics, photonics, acoustics and sensing, tuning of the quantum dot band gap is crucial to receive the required absorption wavelength values. The most common methods today include doping by transition metals, strain via epitaxial growth and quantum confinement. These methods all have limiting disadvantages such has high reaction temperatures, complex and time consuming preparation, and a limited range of materials and films that are capable of enduring the rigorous procedures. An advantageous method to the above involves the incorporation of different amino acids to the crystalline solution of a chosen quantum dot for band gap tuning. This simple method of preparation offers low synthesis temperature and high accuracy of tuning (both up and down). 

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CHM-1540: Sandwich panel and method of its fabrication

Vehicles (marine, air, rail) and the building industry, among others, use sandwich panels: laminated composites containing two stiff skins and a light-density core. To prevent delamination (structural failure) the two skins are normally stitched onto the core. However, the resin used to fill the gaps formed due to stitching considerably increases the panel's weight. This invention suggests the use of light density foam based on expandable microspheres as a replacement for excessive amounts of resin injected, significantly reducing the overall panel weight.

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CHM-1553: Method and apparatus for isolation and analysis of individual cells

This novel system isolates single cells and analyzes each individually. Through the use of ion injection technology, the system enables the introduction of charged molecules to a cell environment without adding volume. This quality is important for cases in which the content is not diluted, such as lysis analysis. The system uses a novel process for cell isolation and analysis of the cell's content or secreted proteins.

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CHM-1558: Microfluidic assay for pathogen detection

Pathogen detection is vitally important in the identification, prevention and treatment of health risks associated with bacterial infections in food safety, water and environmental quality control and clinical diagnosis. The microfluidic assay presented in this invention will enable rapid and continuous one-step testing on a single device at the point-of-need, relieving the dependence on clinically-trained personnel, eliminating the need of several sample preparation steps and enabling significant reduction in the amount of expensive reagents required for detection.
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CHM-1561: Razor blade assembly

The friction-providing material used for stretching the skin while shaving constitutes an important component of modern safety razor design. This invention proposes the use of bio-inspired textured surfaces (mimicking those which crickets employ to enhance friction) to increase skin stretching in disposable safety razor assemblies. Borrowing from nature’s millennia of evolutionary development, it is expected to offer better shave results than current razor designs.

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CHM-1605: Unfaceted micron-sized gold crystals

This invention proposes a method for the preparation of a single, porous curved tunable crystal of gold. The method consists of evaporation and annealing to result in the formation of liquid micro-droplets of Au-Ge. By changing the shape of the droplet the shape of the single crystal can be controlled. Applications include micro-lenses and micro-mirrors, and can be used in drug delivery or highly conductive porous structures such as scaffold for photovoltaic devices.

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CHM-1668: Doping gradient in electro-catalytic materials

Electro-chemical cells requires materials that simultaneously electrically-conduct and allow chemical reactions, activities that conflict with one another. The proposed solution includes a doping gradient strategy such that the dopant materials are appropriate for the function of each region. In the bulk, the material will include a higher concentration of dopants that enhance electron conductivity. At the surface, the material will have a lower concentration of these dopants since they inhibit chemical activity. The advantage is the simultaneous efficiency in both conductivity and reactivity.
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CHM-8013: Novel coolant for corrosion-protection of magnesium alloy engine parts

The trend towards reduced fuel consumption for automobiles has led to an increase in the use of lighter metallic alloys in engines. Aside from weight reduction, magnesium alloys have other advantages such as reduction in materials cost and reduction of manufacturing costs due to a more efficient manufacturing process. Special attention has been placed on magnesium in the past ten years by the automobile industry worldwide. This innovative coolant is designed specifically to protect magnesium alloys from corrosion while also protecting all of the other metals in the engine for an efficient and long-lasting operation.

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CIV-1043: Method of erecting building structures in water basins

Construction of large building structures in seas and other water basins involves installing the building structure onto the floor of the water basin or floating the structure and connecting the base to the basin floor. Current methods in constructing large-scale offshore structures are highly labor-consuming and expensive. We designed a method whereby the prefabricated base for erecting the structure would serve as the foundation of the structure itself, resulting in a construction that is more time efficient and cost efficient.

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CIV-1108: Automated detection of tunnel excavation

Cross-borders smuggling tunnels pose a very serious threat to security. Recent advances in strain measurement by fiber-based Brillouin optical time domain reflectometry (BODTR), led to the development of commercially available systems with sensitivity of less than 5μm and spatial resolution of 1m, thus enabling sufficiently sensitive device, which can detect tunnel excavation through the strains the tunnel causes near the surface.

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CIV-1240 : Plasticizer for concrete

Water-reducing/plasticizing admixtures are used at an increasing rate for the production of both high-strength and normal strength concrete. The increase is due to the wide range of influence these additives have on the rheology of fresh concrete, as well as on the engineering properties of the hardened material. These admixtures improve the workability of concrete at a given water cement ratio or reduce water content in the mix allowing for the production of concrete of increased strength and increased resistance to physical and chemical attack. They also allow for a reduction of both water and cement in order to reduce the concrete cost. As opposed to other conventionally used plasticizers, this admixture is nontoxic, can be stored safely, is made of easily attainable raw materials, is easy to manufacture and is low-cost.

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COM-0500: Wavelength-selectable laser

Fiber-optics is the leading technology for high-bandwidth communications such as Internet, telephones and cable TV networks. Current commercial transmission using a single fiber with a single wave-length can reach throughputs as high as 10 Gbps. Our technology overcomes this limitation by operating a laser with the ability to rapidly switch between different wavelengths. Low fabrication costs and nanosecond switching times allow for a cost-effective solution for increasing the capacity of existing fiber infrastructure. Contact us...

COM-0619: Gamma-ray detector

Gamma-ray detectors have wide applications in fields such as nuclear medicine, environmental monitoring and material testing. By analyzing emitted rays using a gamma-ray spectrometer, diagnostically useful information can be obtained. Some of the methods used for the detection of gamma-rays include Geiger counters, scintillation counters, neutron detectors, semiconductor detectors and variants including CCDs. Our invention improves the fabrication process of detectors using an acoustic wave treatment. This allows for improvements such as increased sensitivity and differentiation between energy levels of the detected rays.

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COM-0699: Recovering underwater scenes using polarization analysis

Current methods for underwater imaging are distance dependent, have low contrast and color recovery, and have poor scene restructuring capabilities. Previous polarization related work is only capable for short distances. The presented method and device uses natural ambient light to provide better visibility and at greater distances. This method improves security adeptness, vessel inspection efficiency, underwater mapping, and search and recovery missions.

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COM-0712: GeomCore - outstanding 3D graphics

GeomCore offers a whole framework that allows three-dimensional geometry to be presented over the World Wide Web. The geometry is presented in an efficient way and allows for a high degree of interaction and collaboration, all in real time. GeomCore’s technology can serve as the basis for numerous applications such as MCAD 3D visualization over the Web, 3D icons and collaborative 3D games.

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COM-0731: Gate diffusion inputs circuit design

Our gate diffusion inputs (GDI) technology is superior when dealing with the rising challenges of digital circuits design. Current methods are based on standard logical gates and are not compatible with the increasing demands for low power designs in the electronics industry. Our technology is simple to implement, cost effective and based on multi-functional building blocks.

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COM-0734: Method for acquisition of video with enhanced resolution

Increasing video resolutions require higher data transfer rates, which can eventually lead to bottlenecks in recording devices. Our technology enables the capture of video at higher resolutions and frame rates using low and midrange camera hardware. Using a sequence of mixed high and low resolution frames, our algorithm constructs a fully high resolution video. In cases when real-time processing is not required, there are no additional hardware requirements. Read more...

COM-0751: Automatic re-meshing from a 2D grid to a 3D model

This technology is a method for re-meshing complex 3D bodies with holes which are typical of CAD/CAM and computer analysis systems in the engineering and medical fields. This method is qualitatively different than other re-meshing methods and offers an efficient solution based on a new approach utilizing topographical knowledge of the body. It also allows for great flexibility in changing the parameters of the meshing (shape of elements, density, adaptability, etc.).

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COM-0753: Optical noise-free microphone

This invention is an innovative method to detect a person’s voice while suppressing any background noise. The optical noise-free microphone (ONFM) is a low-cost, simple and small device that optically detects vibrations directly from the speaker’s skull or from other sound-generating objects such as musical instruments.

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COM-0808: Efficient method of shaping a laser beam

The military industry, as well as those industries involved in the production of semiconductors, medical devices, and vehicles, need improved laser systems in order to satisfy growing customer demands. The efficiency of a laser system is determined by the laser beam power and the resolution output at each point. Existing technologies to improve these qualities are limited and only partially answer industry demands. We combine the advantages of current technologies in a simple, low cost manner to maximize systems performance by shaping its laser beam form.

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COM-0812: Monitoring threshold functions over distributed data sets

A common requirement in many emerging applications is the ability to process, in real time, a continuous high-volume stream of data. Consequently, data stream monitoring in a distributed system is the focus of much research in recent years. Examples of such applications are sensor networks, real-time analysis of financial data and intrusion detection. We present a novel geometric approach utilizing naive, centralized algorithms for efficient arbitrary threshold functions monitoring over distributed data streams without requiring the very high communication overhead common in other methods.

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COM-0819: Hidden point removal

Three-dimensional scanners create a point cloud after scanning an object. When viewing the point cloud of the scanned object it is helpful, and sometimes necessary, to remove points that would be hidden if the object were solid. This innovative technique for removing hidden points is beneficial for a variety of applications such as fast and simple view dependent surface reconstruction and shadow casting. This technique can be utilized for medical applications, geometric modeling, computer games, military applications, security, and architectural design.

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COM-0834: Imaging systems and methods for recovering object visibility

There is a wide spectrum of uses for images taken in scattering media such as fog, water and even in biological tissue. Unfortunately, these images suffer from poor visibility due to backscattering and signal attenuation. Backscatter is especially strong when using artificial illumination. This technological approach which is instant, simple, easy to build and low-cost results in a computational visibility improvement which has already been demonstrated underwater in poor visibility conditions. It also yields a rough estimate of the 3D scene structure and may even be extended to work with multiple illumination sources.

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COM-0884: Object distance and brightness estimation

Optical imaging and ranging technologies are used to acquire the depth and brightness of each object point in a given field of view. Such technologies are used in numerous applications, from home digital cameras to microscopy systems. Existing methods exhibit depth of focus resolution for range estimation. Our technology achieves higher distance accuracy in a wide field of view.

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COM-0894: Improved transistor structures

Field effect transistors (FETs) are devices in which an electric field created by a gate controls the flow of current along the transistor’s channel from the source to the drain. Thin film transistors (TFTs) are a form of this device which can be used as a back-plane for non-emissive displays, like LCDs or electronic ink displays, or for emissive displays based on OLEDs or even for logic circuits. Unfortunately, most low cost TFTs (organic or amorphous silicon) are restricted in the amount of current they can provide which increases the switching time and enhances background noise-all undesirable effects for a transistor. This technology effectively shorts the channel enhancing its conductivity without doping it in any way. All of the potential problems associated with doping such as ion diffusion and charge diffusion are absent offering a thin film transistor with enhanced performance that is able to provide more current than conventional TFTs, reduced switching times and reduced background noise.

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COM-0910: Deep nanopatterning focused ion beam technology

Focused ion beam (FIB) technology is widely used in the semiconductor industry. FIB etching is used to develop and modify optoelectronic and microelectronic devices. However, FIB technology is limited to large scale devices and is incompatible with the industry trend to reduce device dimensions. Our technology is unique and enables nanometric scale FIB lithography.

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COM-0913: Protection of copyrighted material on the web

The internet is increasingly becoming a major source for knowledge and information. Search engines and other web sites that provide information invest extensive resources to meet the user’s demands. Currently, these efforts result in limited information or may lead to legal disputes. Our technology enables a content provider to provide all information without violation of any law. Read more...

COM-0914: Robust silhouette tracking in video streams

Video films in various applications can track non-rigid objects using camera’s visual trackers. Most trackers rely on a common model, which operates under limited conditions, and therefore fails to achieve the needed speed and robustness for flexible tracking. Thanks to an innovative approach, our novel algorithm enables greater flexibility to the motion analysis process so higher accuracy is achieved. Read more...

COM-0944: XPathL-logical language for integrating relational and XML databases

The joint processing of XML and relational data is of major importance in information and knowledge management. Many database management systems support XML data, which is the de facto standard for data representation and exchange over the web. Our method handles conjunctive queries, comprising relational predicates and external predicates, such as XML predicates. The language can be utilized as a target language for higher level constructs or as an embedded query language.

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COM-0945: LED-like photon pair source

Entangled photons have the potential to provide improved signal-to-noise ratio (SNR) and immunity to eavesdropping in communication applications. A source for such photons is necessary for higher quality, more secure optical communications. However, current photon source devices are impractical for industrial use. Our technology enables high performance, commercially viable entangled photon sources.

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COM-0948: Efficient real-time acquisition of textured 3D video

Reproducing a live scene-such as a football game-with 3D cameras is far from being feasible. When filming in 3D, the camera’s view is often obstructed by objects in the scene. For this reason multiple cameras are needed in order to capture the entire scene, which can result in unreasonable costs. Our algorithm enables the substitution of some of the 3D cameras with ordinary video cameras, and is suited for real-time operation.

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COM-0954: Polarization-multiplexing based passive optical networks

Polarization-multiplexing based passive optical networks passive optical networks (PON) are used for high speed digital communication such as video, data and voice. Currently, massive deployment of optical fiber infrastructure is underway to enable this technology. This creates problems of inflexibility to future adjustment of the network due to the growing number of users and massive data. Our technology provides a cost effective solution that works on the existing infrastructure.

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COM-0966: Blind reconstruction of multi-band analog signals

Reconstruction of multi-band signals is a challenge in the field of signal processing. Some of today’s methods require a high sampling rate, and obtaining such a rate requires expensive systems. Other methods require prior knowledge, which is not always available. Our technology enables perfect reconstruction of multi-band analog signals at a minimal sample rate and with no need for prior information.

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COM-0970: Distorted signal recovery

Reconstruction of a signal from its distorted samples is a common scenario in acquisition devices such as sensors and detectors. Current methods developed for these situations are based on idealized assumptions or are limited in application. Our technology is practical and applicable to numerous systems.

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COM-0987: BENoC-bus enhancement network on chip

Network on chip (NoC) is the future of VLSI interconnects. The technology enables improved chip performance in numerous aspects such as power consumption and data transfer rate. Several drawbacks are to be worked out to accelerate its acceptance as an industry standard. Our technology solves some of these issues and increases system operation efficiency at a low cost.

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COM-0992: Disk reclustering for faster XML databases

PIXSAR is an algorithm that is capable of efficiently rearranging an XML-based database. It does so by treating database clustering as an augmented tree partitioning problem and adjusting the data physical layout according to the dynamic workload. iPIXSAR, an extension, is able to do so in the presence of multiple-indexes over the database.

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COM-1050: Optical logic gate

Future digital communication systems are expected to be faster and capable of transferring larger amounts of data. As current electronically-based systems will not be able to handle these demands, alternative solutions are required. Optical networking is expected to provide faster throughput rates and wider bandwidth, but it requires extremely fast switches, which must operate in the pico-second range. Our optical gate opens the door to a fully-integrated, all optical communications network.

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COM-1067: Maximizing restorable throughput in MPLS networks

MPLS recovery mechanisms algorithms are used by large network operators to assure high QoS in case of failure by pre-establishing backup network paths. Current networks use simple methods for calculating feasible primary and backup paths. However, these paths may not efficiently use the network resources and may block other traffic from being serviced, thereby reducing profitability. Our highly efficient algorithm allows network operators to maximize their revenues by allocating primary and backup paths more efficiently without compromising QoS. Read more...

COM-1071: Texture and image interpolation using Markov models

Image upscaling technologies are in demand due to the influx of high-definition displays and the prevalence of low-resolution content. Our algorithm allows for the restoration of textured images out of low-resolution or low-quality ones. The algorithm analyzes the image statistically to achieve superior results as compared to simple methods such as bicubic and bilinear. This also enables high-ratio compression for textures and introduces an innovative criterion for comparison of image textures, which may be used for different applications. Read more...

COM-1080: Pinpoint microphone

The intuitive pin-point selection of an individual within a crowd to detect their voice has several important applications from highly directional hearing aids to eavesdropping on, or identifying a suspect in public. This invention detects sound at a distance with the required sub-nanometer sensitivity, surmounting the inherent difficulties of optical detection of reflections from scattering surfaces, unstable detection geometries, environmental disturbances and background interference. Read more...

COM-1094: Advanced query language for social networks

As online social networks become increasingly popular, the amount of available data is constantly on the rise. Search options for end users, however, have remained limited. Our query language opens up new possibilities for retrieving useful data from these vast databases. This language enables new features not implemented today due to resource limitations, such as retrieving the shortest “acquaintance path” between users under various constraints. Read more...

COM-1102: CMOS-SOI-MEMS thermal sensors for THz imaging

This invention is aimed towards achieving a focal plane array for passive or active imaging in a wide bandwidth of 0.6-1.5THz-by pursuing a new approach and introducing multiple innovations, one of which is based on uncooled thermally isolated CMOS-SOI transistors (TeraMOS).

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COM-1103: Complex barycentric coordinates

Barycentric coordinates are heavily used in computer graphics applications to generalize a set of given data values. Traditionally, the coordinates are required to be real and positive. We relax this requirement by allowing the barycentric coordinates to be complex numbers which lead to several powerful advantages. These new coordinates are highly effective in generating conformal mappings from a given planar source region to a planar target region. Complex barycentric coordinates can be used for image manipulation, shape deformation, animation, data interpolation, color interpolation and parameterization. Read more...

COM-1104: Ternary content-addressable memory with fast error detection

Ternary content-addressable memory (TCAM) devices are increasingly being used for performing high-speed classification of data packets required by networking applications such as routing, monitoring and security. The parallel-access properties of TCAM devices make them prone to errors which standard error detection schemes are not designed to handle. Our technology is a parallel error detection scheme which is optimized for TCAM. It allows an order of magnitude reduction in the number of lookups required for the error location process, thereby increasing performance and reliability. Contact us...

COM-1106: Compact and wideband tapered slot antenna for WPAN applications

The communication industry is growing at phenomenal rate. A clear trend is the future development of wireless personal area networks (WPAN) operating in the 60 GHz millimeter-wave band. WPAN devices require low-cost antennas that are not only compact and integrable with RF modules, but also efficient and wideband. Current technologies are expensive and exhibit poor performance rendering them unsuitable for many applications. Our technology provides a generic and efficient solution to this growing need.

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COM-1117: Texture mapping of 3D models using casual images

Texture mapping from 2D images is a method for adding detail, surface texture or color to a computer-generated graphic or three-dimensional model, commonly used in computer graphics, computer games, virtual worlds, etc. In the known solutions to the problem, when a casual image is used, high distortions in the texturing occur. Our technology avoids such distortions by formulating the mapping as a camera projection matrix. Read more...

COM-1119: Method for images saliency detection

The novelties in automatic creation of digital albums, digital cameras and digital image editing tools assisted in developing advanced image based applications. Nevertheless, these products produce shape images that are often aesthetically unsatisfactory, partly due to their failure to extract the interesting part of an image, and partly due to their limitations in extracting only rectangular regions. Our technology is significantly better at recognizing, defining and extracting regions of interest (ROIs) from image and can be applied in a wide variety of applications.

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COM-1122: Wideband analog to digital conversion and low rate baseband processing

Radio frequency (RF) technology enables the modulation of narrowband signals through high carrier frequencies. Conventional analog to digital converters (ADC’s) have inherent bandwidth and maximal frequency limitations. Our novel technology enables the design of an ADC device for input in the wideband regime of over 20 GHz and for generation of a baseband sequence which corresponds to any specific region of the spectrum without the need for prior reconstruction.

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COM-1139: Highly sensitive detector for infrared wavelengths

There is a growing need for enhanced sensitivity in the measurements of optical phenomena. The most sensitive of optical detectors, single photon detectors (SPD’s) can be used to enhance medical and diagnostic imaging, chemical analysis, laser scanning, laser ranging, material characterization, quantum information processing and communication, and scientific research. Most SPD’s are incapable of detecting photons in the infrared wavelength and those that are usually plagued by poor quantum efficiency or require very low operating temperatures (about 10K). However, this invention is an important step closer in the effort to detect a single infrared photon at almost room temperature with high quantum efficiency.

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COM-1143: Multi-phase interferometer

Interferometric optical sensing is perhaps the method of choice for the measurement of small displacements, refractive index changes and surface irregularities. This technique is applied in a wide array of different disciplines, including the detection of vibrating surfaces, engineering product testing, and medical monitoring. However, in an uncontrolled environment, and more so in applications with a large stand-off, interferometers suffer a major difficulty: the drift in the sensitive "work-point" of the interferometer due to instabilities in the environment or the stand-off distance. The multi-phase interferometer alleviates such difficulties in a low-cost and compact implementation.

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COM-1150: Monitoring distributed data sets

Various systems and applications perform monitoring of data streams in a distributed environment. Such applications include, for example, sensor networked, distributed websites, etc. Existing methods for data stream monitoring require high computational costs when monitoring non-linear functions. They are also limited in the number of distributed nodes and monitored objects. This method employs a novel geometric approach to monitor the data stream at much greater efficiency and with many fewer restrictions.

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COM-1154: Photonic-enabled ultra-high-speed RF analog-to-digital conversion

Digital signal processing (DSP) has revolutionized modern communications and radar systems and is an integral part of many other industries. For broadband systems, the application of DSP systems is hindered by the difficulty in capturing (digitizing) the wideband signal in real time. Although wideband analog-to-digital converters (ADC) are in high demand, a satisfactory solution doesn’t exist yet in the market. This technology utilizes a number of innovations to create systems that easily outperform existing solutions.

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COM-1157: Novel and powerful enhancement of measurement systems’ resolution

This invention is a novel and powerful method which enables the enhancement of measurement equipment resolution beyond its physical limits in cases where the signal being measured is sparse in a known basis. Most measure objects (natural and artificial) are sparse, i.e., they contain many coefficients close or equal to zero when represented in some basis. This is the first time this approach has been employed to tackle this problem. The method has been demonstrated to enhance the resolution of an optical microscope by a factor of ~10 beyond the fundamental diffraction limit. Similar resolution enhancement capabilities have been shown, where a laser pulse consisting of three 150 ps subpulses has been successfully and accurately reconstructed following acquisition by a “slow” photodiode with a 1000 ps rise time. This technique is very general, and can be utilized in any sensing/ detection/ data acquisition scheme.

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COM-1194: Speckle-noise elimination in holographic projection

The demand for three-dimensional images in popular entertainment and information systems is growing quickly. Speckle noise is a major disturbance in phase-only holographic projections but current solutions for the removal of this interference have many drawbacks. They either fail to remove the interference completely or require a significantly more complex calculation method demanding more computing resources reducing the possible rate of projection and increasing the size of the holographic unit. Our method completely removes the speckle noise without excessive computation or additional optical components allowing for unadulterated high-rate holographic projections. Read more...

COM-1197: Social networks interaction protocol

Social network interaction protocol is an automated feature involving intelligent communication between large numbers of participants in social networks. Known implanted features like allow structured communication regarding events, but they are lack a wide range of communication and dissemination options. We managed to expand social network communication opportunities by creating a new generic protocol that can be modified by participants. Read more...

COM-1204: Multi-core XML query processing

Multi-core XML processing is a method that allows better processing performance of an XML Twig Pattern query. The known processing method use sequential algorithms that deal with a single query processing, but since modern computers have multi-core processors we managed to optimize the processing performance of a twig pattern XML query by parallelizing two existing sequential algorithms and in this way create new novel and efficient algorithms. Read more...

COM-1253: CMOS-SOI-MEMS thermal antenna for THz thermal imaging

Thermal antennas couple thermal radiation to thermal sensors by converting Electromagnetic radiation directly into heat. Applications include THz sensors where the challenge is to achieve high efficient coupling between the thermal radiation irradiating large pixels and the tiny TeraMOS sensor described above. Additional applications include IR pixels where with the present invention the thermal time constant may be reduced significantly.

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COM-1282: Mitigation of inter-cell coupling effects in NAND flash memory

NAND flash memory is a popular data storage facility at various electronic devices. However, it suffers from an inter-cell coupling effect which reduces the memory functionality. An innovative method improves the NAND flash memory operations by diminish the inter-cell coupling effect.

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COM-1295: Three-photon counting by three photon absorption

Photon counting is the key enabler of the revolution in experimental quantum optics, as well as for a variety of quantum information applications achieved over the past decade. It also plays an important role in classical applications involving extremely low-light intensities in a wide range of fields including biological imaging and optical communications. Significant efforts have been made to develop photon counters able to detect high photon number states which can provide unique solutions for enhanced-sensitivity metrology and quantum computing. This technology is a sensitive three-photon counter in which input photons are absorbed as triplets by three-photon absorption (3PA) allowing for ultrafast detection of photon triplets and extraction of the temporal shape of a fsec pulse without direction-of-time ambiguity and with no need for spectral measurements.

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COM-1304: THz source

THz radiation bridges the gap between microwaves and infrared. Until recently, this spectral range has received limited attention due to the lack of efficient and low/moderate cost THz sources and detectors. However, there are a number of promising applications such as THz imaging (concealed weapon and explosive detection) and THz spectroscopy (pharmaceutical, biomedical, and materials inspection applications). Successful exploitation of the potential of THz technology requires the availability of low cost, versatile and powerful THz emitters as well as highly sensitive, un-cooled and small detectors. The presented invention uses a blackbody apparatus to enable the manufacture of relatively low-cost THz systems to meet these needs.

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COM-1322: Low-complexity, optically coherent and self-coherent signal processing

Today, the new generation of optical transmission systems is based on coherent detection using local oscillator lasers in the optical receivers. However, with current receivers, existing methods suffer from excess phase noise and are incapable of sustaining large and/or rapid frequency drifts. This drawback of the local oscillator lasers, coupled with the high cost of tunable highly coherent lasers, impede on the advantages of coherent detection. The proposed method is an improved, lower complexity signal processing algorithm for performing carrier recovery (phase and frequency estimation and compensation) for coherent optical detection. The algorithm significantly relaxes the laser requirements. Conversely, for a given laser system, the suppressed phase noise greatly improves performance. Furthermore, this algorithm allows, for the first time, robust, low cost, practical optical transmission systems based on self-coherent detection, attaining the advantages of coherent detection without the local oscillator laser in the receiver.

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COM-1342: Supply chain simulator

Management of supply chains is a major issue in operations, and teaching supply chain management and supporting decisions in this area is a real need for many businesses as well as academic institutions. However, no analytical model can express the true richness of any real world supply chain problem. Available models either have a very limited range of scenarios or are so all-inclusive that they lose the focus on supply chains. We have designed software that enables simulating complicated supply chain models and can interface with existing software as well as generate scenarios based on real supply chains stored in the system. The simulation allows students on the one hand, and business users (like inventory managers) on the other hand to gain a deeper understanding of how supply chains work. Read more...

COM-1343: Accelerating flash memory performance by partial sensing

Flash memory is a non-volatile memory component, widely used in modern electronic systems. The growing demand for high performance computing along with high capacity data storage stimulates flash technology development. The increase in capacity, often accompanied by performance reduction (due to the use of multiple charge levels), makes increasing performance a critical task. Current methods used to accelerate flash memory performance induce errors in the data. The technique presented uses a novel algorithm to exploit the actual capabilities of each part of the memory chip at any given time, thereby performing significantly accelerated read, write and erase operations without inducing undetected errors. Yet, implementation of the technique requires no changes in the core technology or fabrication process.

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COM-1351: Methods and systems of supervised learning of semantic relatedness

Semantic relatedness is the quantification of the intensity with which two objects are related to each other. In recent years, the problem of automatically determining semantic relatedness has been steadily gaining attention among statistical natural language processing and artificial intelligence researchers. This method is a novel structure-free supervised approach to learning semantic relatedness from examples. With this model, semantic relatedness learning is treated as a binary classification problem where each instance encodes the relative relatedness of two term pairs.

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COM-1352: 3D graphical user interface for presentation software

Many industries are intensive users of 3D. However, their inability to present 3D information in their everyday workplace and outside their natural 3D working environment (e.g. a CT scanner) is a significant operational and financial drawback. Current 2D presentation tools are less efficient and are prone to misunderstandings and errors of misinterpretation when 3D content is involved and this has a direct and substantial economic implication on these industries. Currently, presentations with 3D content are typically constructed by specialized production teams that are extremely expensive. The technology presented is of a multi-modalities presentation software that will also provide the average user with the ability to create 3D presentations with 3D content at a fraction of the cost and will allow the presenter to annotate, transform,  animate, and arbitrarily manipulate (e.g. slice) 3D content in a seamless manner within the presentations.

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COM-1361: Fiber optical superconducting nanowire single photon detector

There is a growing demand for increasingly sensitive optical detectors for commercial and academic use. They can be used for quantum communications, astronomical research, deep space communication and many forms of academic research. This invention is an improved superconducting nanowire single photon detector with very low noise and a high detection rate over a wide range of light waves.

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COM-1364: Improvements to image reconstruction in computed tomography

Computed tomography (CT) has become a very important tool in medical imaging and is used for preventive medicine or disease screening. CT images are produced by reconstruction algorithms that provide images of different resolutions and noise levels. Current CT machines use high-dose radiation in order to get an acceptable image quality for clinical diagnosis; however they are very slow and require the CT machines to be modified. The proposed technology is an algorithm that enables a substantial reduction in radiation dose in CT imaging, and being based on off-line learning and sparse representations, leads to fast image reconstruction and one that is robust and adjusted to the machine’s imperfections. Read more...

COM-1389: Hyper-redundant robot with two active degrees of freedom mechanism

An elephant-like robotic trunk having large workspace, which can curl up in free space carrying heavy loads and bypassing obstacles can be used for search and rescue applications and bomb disposal while mounted on a mobile platform. The basic mechanism is composed of two motors independently rotating two cylinders which act as a mechanical “exoskeleton” for carrying heavy loads and ensuring high rigidity and accuracy at the edge of the mechanism. The mechanism can be reduced in size and used also in medical applications where there is a need for accurately reaching and looking around obstacles while maintaining a rigid structure for delivering surgical tools inside the body.

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COM-1400: Carrier phase estimation for optically coherent QPSK

The proposed technology is a novel carrier phase and frequency recovery system that automatically cancels local oscillator (LO) frequency offsets. The system exhibits significantly improved phase noise tolerance and is extremely robust to rapid intradyne frequency drifts (10GHz/s chirp) which would break down conventional Mth-power frequency estimators. It also outperforms conventional schemes in mean square phase error, with low complexity linear processing, using a low number of complex-multiply-adds.

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COM-1401: A parallel twig join algorithm for XML processing using a GPGPU

Current algorithms to match XML query twig patterns in a parallel GPU multi-threaded computing platform are only fit for systems with a maximum of several dozen threads. The technology presented is a novel algorithm for matching twig patterns in large XML documents, using GPU. The algorithm efficiently exploits both the high-bandwidth GPU memory interface and the lower-bandwidth CPU main memory and is suitable for systems with many hundreds of threads. The invention can be used to upgrade database systems that support XML documents to work in multi-core GPU environments and can significantly improve their performance.

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COM-1431: Real-time, 3D digital-human for communication online

Most communication patterns on the web are done via symbolic communication systems using spoken or written language. However, it has been repeatedly shown that less than 10% of human exchange of information is done through words; the rest is through non-verbal communication such as posture, facial expressions, unaware perception of cues, etc. Current technologies do not have the ability to accurately communicate the other 90% of information exchange in 3D. The technology presented is a physiological avatar that represents the human in real time with high enough visual resolution to show emotional changes and just noticeable differences (e.g. fluctuations of the eye pupil, separated hair). The avatar is also able to show physiological functions like brain activities as well as heart rate with a system that transfers this information wirelessly, creating the experience of 3D face-to-face interaction.

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COM-1451: Parallelized decision forest builder for streaming multiprocessors

Very large data sets with large numbers of attributes are currently only able to be processed on expensive and complex computing clusters. The present technology is a new method which takes advantage of the modern large (1GB+) onboard GPU device memory as well as large onboard CPU RAM in order to map the building of a single randomized decision tree to a GPU, multiple GPUs or multiple CPUs. The technology can be applied to very large datasets of training data on commodity hardware for a fraction of the startup and runtime costs required to perform the same learning method on a cluster.

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COM-1466: Sub-Nyquist radar via Doppler focusing

Standard radar systems today sample and digitally process the received signal at its Nyquist rate, this rate can be up to hundreds of MHz and higher for modern systems. The drawback of this approach is that Nyquist rate sampling and processing is not always possible, or its price is too high. The algorithm enables radar receivers to dramatically decrease their hardware requirements, while maintaining the same performance for conventional Nyquist rate sampling and processing for large bandwidths. The technology combines the lower cost of sub-Nyquist sampling and processing, with the Nyquist rate performance.

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COM-1468: Query processing for graph databases

Graphics processing units (GPUs), originally designed for graphics rendering tasks, have evolved into massively multi-threaded, multicore processors for CPUs. The challenge is how to process queries on graph databases using single instruction, multiple data (SIMD) technology, in particular GPUs. We present what is most likely the first parallel algorithm that uses GPUs to accelerate the processing of graph database queries. This algorithm significantly improves the performance of such database systems.

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COM-1471: Frequency domain beamforming in ultrasound imaging

Most ultrasound imaging systems use multiple transducer elements to transmit and receive acoustic pulses. Beamforming of the signals detected by the individual elements of the array increases the signal-to-noise ratio and is performed in the digital domain, implying that the analog signals detected at the receiver elements are first sampled. Current methods either only reduce the processing rate while the sampling rate remains unchanged or are unable to capture a speckle pattern which is of high importance in medical imaging. The presented technology is a novel method that significantly reduces (up to 16 fold reduction) the sampling and consequently the processing rates without compromising the quality of an image. This method is applicable to both medical and nondestructive testing ultrasound applications and other narrowband based techniques like sonar can benefit from this method.

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COM-1480: Polar multi-symbol delay detection carrier recovery

Carrier recovery (CR) in electrical and optical communication is typically a hardware intensive operation, especially when requiring high precision. The presented technology provides a particularly effective hardware realization while also providing carrier frequency and phase recovery as well as providing non-linear cross-phase modulation correction. The polar-domain operation allows multiplier-free implementation, significantly reducing hardware realization complexity.

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COM-1482: Minimum maximum-level programming

NAND flash is currently the most prominent non-volatile semiconductor memory technology, used mostly for storage. Both flash and phase-change memory employ multi-level cells (MLC), while beneficial in terms of storage capacity and cost per bit, MLC comes at a performance penalty. The technology presented is an innovative memory architecture, composed of encoder, decoder and address-to-cells mapping. The technology improves the best known average page write time, has an accelerated read time, and is proven to achieve the upper bound of write speed. The proposed scheme does not require data redundancy, reduces energy consumption and is suitable to every product that employs flash or phase change memory.

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COM-1483: Retired page utilization for improved write capacity of solid state drives

NAND Flash is presently the most prominent solid-state memory technology. While SSD offer higher performance and other advantages over mechanical magnetic hard disk drives (HDD), their per-bit cost is much higher. Current methods to reduce cost however sharply degrade the tolerable number of erasures of a cell, thereby limiting product lifetime. The presented technology is an innovative memory management scheme that significantly boosts current write-capacity enhancing schemes with negligible capacity and performance overhead. This is done by managing “where” to write in addition to “what” to write. Specifically, RPU adds spatial consideration to any write-once memory coding.

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COM-1484: Continuous flow multithreading architecture

Switch on event multithreading (SoE MT) is a low-power process suffering from performance drawbacks due to the relatively high thread-switch penalty. Simultaneous multithreading (SMT) has limitations in the number of threads running in the machine due to its complexity. The presented technology CMFT Architecture can use SRAM or other emerging memory technologies to enhance the performance of the processor and support more threads while consuming significantly less power. This architecture can be used in any general purpose processors suitable for mobile products, personal computers, embedded systems and servers.

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COM-1488: Management and recovery of distributed storage of replicas

Contemporary storage systems often maintain at least three replicas of all data, reducing the risk of permanent data loss due to simultaneous disk failures. The cost of the additional copies is a reduction in usable storage space, with increased network traffic and higher power consumption. The presented technology employs an inexpensive add-on device attached to each disk, enabling storage systems to withstand simultaneous failures while requiring only two data replicas and minimizing cost, network, and power overheads.

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COM-1495: Charge-discharge electro-optical microring modulator

Silicon integrated electro-optical modulators are essential for inserting information into optical channels in high-speed optical communication technology. Most of today’s modulators have many disadvantages, especially in integrated circuits due to its large length and the necessity for velocity matching between the electrical driven waves to optical carrier waves. The presented technology is a new structure of the modulator which allows for significantly higher modulation band widths, continuous modulation without distortions due to “memory effect” of the resonator and wide linear wide band width modulation, which opens the perspective of fast and effective analog modulation.

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COM-1496: Plasmonic Horn Antenna

By combining the use of single photon avalanche diode (SPAD) pixels with CMOS technology, flash detection benefits from all the advantages of CMOS imaging technologies, providing a matured, low cost technology for detecting weapon muzzle flashes. With this new method, as well as a novel optical filter, non-shooting based flashes are filtered out and the number of false alarms is reduced, even though these sensors are acting on the complex silicon-sensitive wavelength range. Read more...

COM-1508: A method and device for identity verification in cyberspace

Identification or verification through biometrics is performed by re-sampling the traits of an individual and comparing the sampled and recorded traits. Currently there are no biometrics identifications in the cyberspace while popular biometrics in the physical world such as fingerprints are easy to circumvent. Using the presented cognitive-behavioral biometry through instructions and reactions achieves a high level of security in the cyberspace.

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COM-1510: System for improving host page-swapping use

Host page-swapping is usually required when the virtual machine (VM) does not cooperate and is also used as a complementary method for other memory over-commitment mechanisms. However, this induces significant overheads for common workloads. In addition, other memory overcommitment solutions that may perform better are imperfect and cannot always be applied. The presented system reads and prefetches pages from the VM disk when the VM reads data that resides on the VM disk by remapping the host free memory pages upon VM pages reallocation instead of swapping pages in. This system performs sequential file read up to 20 times faster than existing host-swapping solutions.

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COM-1520: Natural machine interface system

The need for calculating the relative position of a machine part with regards to other elements in the environment or with regards to other machines and machines’ parts is especially important when coordinating and synchronizing two or more machines (i.e. robots) in performing a given task. Robots can share their parts positions but determining the relative positions of one with respect to the other can be complicated and requires a set of sensors and specially designed code. The current invention defines a new technology for Natural Machine Interface (NMI) that allows controllers to dynamically detect machine parts and positions relative to other parts in the environment as well as to communicate between themselves using a Natural User Interface system as a base, combined with other resources.

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COM-1521: Method and system for acoustic levitation

The production and inspection of electronic components created on silicon wafers carries a major concern of contamination through microscopic particles. One solution is to levitate the silicon wafer, thereby removing any physical contact with a hard surface. However, the solutions used today involve pumping the air to produce this levitation. As a result of the pumping device, this air cannot be cleaned to a sufficient level. Another solution uses acoustic levitation through standing waves, avoiding the contamination issue. However, current designs have no means to control a wafer's motion in practice. Our method, using a layout of several linear actuators, creates levitation through a layer of compressed air. This solution is clean from sources of contamination, can control levitation and rotation, and reduces wear on the wafer.

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COM-1549: Spectral generalized multi-dimensional scaling

Shape analysis and matching is commonly used in computer aided diagnostics in medicine, virtual dressing, computer graphics, and computer aided design. Matching non-rigid or deformable shapes, while preserving the distances between pairs of points on the shape is a significant challenge. Known solutions either solve a combinatorial problem, for which the complexity is exponential, or use heuristics to find approximate solutions. The invented algorithm naturally casts the framework for matching deformable shapes into the spectral domain with a novel functional map representation.

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COM-1550: Spectral multidimensional scaling

Multi-Dimensional Scaling aims to reduce the dimensionality of a data set by embedding it in a low dimensional flat space so that it is possible to compare, categorize, and correspond between isometric shapes. However, the computation of all the inter-distances is computationally demanding in both space and time. Methods using subsampling and a reduced set of points tend to be slow, complicated, unable to handle enough points and likely to lose some of the geometric structure of the information. The proposed method is to use the notion of smooth interpolation. The mathematical relation that comes from this justifies the spectral embedding of the geodesic distance function, while the examples demonstrate its usefulness for accurate and efficient shape analysis, matching in computer-aided diagnostics in medicine, big data reduction, big data simplification, and big data visualization.
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COM-1556: Voice channel based device for data exploration and integration

Radio receivers (RRs) are used on a daily basis by both individuals and industries to deliver news, music, advertisements and programs. They are easy to operate and present a standard interface in terms of user-controlled functionality (channel and volume control, mute function etc). This invention deals with extending the functionality of RRs. The idea is to update existing devices to produce a new set of capabilities. Application programs are added to the device, which detect either eye, hand, head movements, touch of radio screen or surface, voice command, whistle or other forms of airflow.

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COM-1564: Resistive random-access memory based multistate register

When investigating memory structures, we are looking for speed and efficiency. Although SRAM is a commonly used memory technology, its low density and high static power limit the amount of data that can be stored with it. Resistive RAM (RRAM), on the other hand, has an improved density. Conventional RRAM requires addresses and a specific sensing mechanism, based on a sense amplifier, which has relatively high area. The presented technology is a novel memory structure – a RRAM-based multistate register (MPR). Here, the switching procedure between active bits does not require a sense amplifier and is relatively simple and fast. MPRs can be used as pipeline registers for processors, especially multithreaded processors, register files of processors, memory cells and more.

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COM-1565: Logic gates with resistive memory devices

Conventional computer architecture is problematic for memory-intensive applications due to the need to read and write from the memory, where the bottleneck is the data transfer and not the processing itself. To improve the performance and reduce the power of these applications, special purpose accelerators are usually used, although the need to transfer the data is still the major limitation. The presented invention is a novel method for implementing logic gates using only memristors. The topology of the Memristor Aided Logic (MAGIC) gates allows it to be fabricated within the memory, allowing for the performance of logic within the memory, without the need to have a different circuitry or to transfer the storage mechanism, ultimately reducing bandwidth, reducing power, improving parallelism, and improving the performance of computing systems.

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COM-1569: Sound-based feature enhancement of surfaces

The challenge of automatically generating caricatures occupied researchers since the 1980's. Once an algorithm was created which automatically generates caricatures from a given surface, using its intrinsic geometric values and is invariant to the surface, it becomes possible to align the caricaturization with sounds. The presented algorithm, which can be applied in various depth-video or music based entertainment, synchronizes surface feature enhancements with sound, allowing the user to create video clips of changing facial features. 

 
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COM-1573: Infrared sensor and focal plane array

For slow thermal sensors, there are no-known circuit or device techniques to reduce the inherent sensor noise. The established methodology of noise reduction, known as correlated double sampling (CDS) is not applicable. Although CMOS transistors have the advantage of low power usage, the technological issue with CMOS transistors is the high low frequency 1/f noise. The new invention replaces the micro/nano machined TMOS with the nano-machined BiCMOS T-SiGe hetero junction bipolar transistor (HBT), which exhibits very low 1/f low-frequency noise. By applying BiCMOS technology, the readout circuitry may be implemented in low power CMOS transistors. Market reports indicate that the coming MEMS killer applications are IR sensors and imagers. By applying BiCMOS technology, the readout circuitry may be implemented in low power CMOS technology. Thus, the limiting aspect of TMOS (noise) is removed while the advantages of CMOS (low power) are retained.

 
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COM-1574: Massively multi-threaded computer processor

Energy consumption has become the primary concern of processor designers and the evaluation by which processors are measured. Because of their energy-efficiency, the GPGPU class of processors is gaining popularity and constitutes a multi-billion dollar market. GPGPUs employ a single-instruction multiple-threads (SIMT) execution model in which a problem is decomposed into multiple threads of execution, all executing exactly the same instructions but operating on different data. The presented invention is a reconfigurable processor design that is completely different from existing GPGPUs and is 2x more power efficient than the current state-of-the-art.

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COM-1578: A distributed approach for cloud elasticity

A fundamental capability of cloud computing is elasticity, i.e., the ability to dynamically change the amount of allocated resources. This is typically done by adjusting the number of VMs running a service based on the current demand for that service. For large services, centralized management is impractical and distributed methods should be employed. In such settings, no single component has full information on demand and service quality, thus elasticity becomes a real challenge. The presented method addresses this challenge by proposing a novel elasticity scheme that enables fully distributed management of large cloud services. Our fully distributed scheme can easily adapt to varying loads, effectively minimizing the number of VMs leased from the cloud, and, consequently, the operation cost, while meeting SLA requirements.

 

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COM-1582: Block mapping inside the disk controller

Modern systems include multiple components that need to access the disk – from virtual machines to various accelerator devices. However, existing systems require that all file accesses be delegated to the operating system/hypervisor for the logical-to-physical mapping of files to disk blocks as well as to provide access permissions. This burdens the system’s performance and power consumption. This invention adds a mapping mechanism to the disk controller that enables hardware and software entities in the computer to securely and directly access their files with low latency and high bandwidth access by removing the CPU and the management software system (operating system/hypervisor) from the critical path of disk data transfers. This mechanism also enforces access permissions.

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COM-1596: Self-coherent robust spectrally efficient optical transmission systems

In the field of short-reach optical transmission links, there is a need for cost-effective and spectrally efficient links. Many options have been considered for this purpose. Using local oscillator lasers in the receiver provides the spectral efficiency but not the cost effectiveness. Self-coherent links, on the other hand, send the local oscillator optical signal remotely from the transmitter as a pilot, but the separation of the cross-talk requires investing resources which reduce spectral efficiency. Moreover, polarization multiplexing is hard to achieve with such scheme. The presented invention further augments the spectral efficiency of self-coherent heterodyne systems as well as the power efficiency, while being robust to impairments. 

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COM-1607: Structured light generation and processing on a mobile device

While projectors and cameras have each recently become available in mobile devices, no manufacturers have aligned their optical axes to synchronize them, leaving the users unable to take advantage of structured light projection and imaging. The proposed system and method are a novel solution to this problem, enriching functionality by angling the projection image while coordinating the camera’s trigger module. This method takes advantage of the existing hardware and computing standards and can be applied to forms of human-computer interaction as well as existing cellphone technologies. 

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COM-1618: 2D and 3D image editing using image level set trees

The performance of image editing tasks, such as segmentation and colorization, from partial user input, is done by examining minimal distances between image pixels. Known solutions work for discrete approximations of the original shortest path problem. Erroneous editing results due to approximate minimal distances produced by known solutions. The proposed invention uses a tree of image level sets for calculation of minimal distances between image pixels without introducing approximation error. This computes a solution of the original minimal distance problem, while maintaining the same linear algorithm complexity. This is useful for image and video segmentation, matting objects into a different background, and image colorization, to be used in commercial image editing programs or a part of mobile image editing applications.

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COM-1619: Memristive Akers logic arrays

In the coming generations of computing systems, part of the computation is envisioned to be done within memory. Current in-memory techniques suffer from bad integration between logic and memory processes. The presented invention is a hardware version of a modified Akers logic array with memristors which combines memory and logic operations, opening up opportunities for novel non-von Neumann computer architectures, while reducing power and enhancing memory bandwidth. This is especially beneficial for in-memory computing.

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COM-1620: Multi-degree-of-freedom stabilization of large-scale photonic integrated circuits

Photonic Integrated Circuits (PIC) have multiple relatively slow tuning degrees of freedom (DOF), that must be adjusted in order to stabilize the PICs to their optimum operating points. Methods are needed to perform this stabilization. Without such methods, large scale integration of many photonic devices on the PIC would not be possible. The presented invention utilizes art ES control methodology with a digital iterative frame-based Discrete-Multi-Tone (DMT) novel method. This improves ES control performance significantly and enables adopting iterative methods of unconstrained optimization of memoryless maps, in order to better address the problem at hand, namely stabilization of either PICs or any generic systems with   multi-dimensional DOFs at their optimum operating points.

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COM-1634: Channel estimation for coherent optical detection

Channel estimation can be problematic with regard to timing recovery and phase recovery for coherent optical detection, as well as for sub-banded filter bank based optical transmission. Difficulties arise when estimating over a broadband channel. The presented method estimates timing offset (coarse and fine) estimation using Golay complementary codes, which is a method to improve tolerance to laser and non-linear phase noise based on non-redundant interleaving. This method improves photonic optical communication for long-haul, metro, and short-haul and is low-complexity.

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COM-1637: Terrestrially observable displays from space

Advertising has recently taken on a new arena, creating signs in space that would be visible from the ground. However, known solutions require large satellites and expensive (heavy) deployment mechanisms and resources. The presented method introduces the usage of nano-satellites for forming the signs. This would enable easy display of changing signs over different territories and time windows. Additionally, this method takes into account the constraints on available energy as well as possibilities of exploiting sunlight for the sign formation. This solution can also be applied to the display of disaster warnings or during major national celebrations.
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COM-1666: Saving flash erase costs using write-once-memory codes

Flash based solid state disks (SSD) are widely used due to their short read and write latencies and increasing throughput. However, once flash cells are written upon, they must be erased before they can be rewritten. These comparatively slow erasures, along with the additional overheads they incur, significantly slow down pending read and write operations. In addition, their reliability deteriorates over time below an acceptable level. The presented technique for reducing block erasures uses write-once memory (WOM) codes. WOM codes alter the logical data before it is physically written, thus allowing the reuse of cells for multiple writes. This can be applied to any Flash based product, including USB devices, SSDs, smart-phones, cameras etc., to reduce erase operations and extend the media’s lifetime and improve its performance.

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COM-1670: Efficient functional in-plane focusing devices

Plasmonic Lenses are of substantial importance in the field of nano-plasmonics in which they are used to focus waves on a single small spot, as well as playing a role in functional focusing, which involves conditioning the existence of a focal spot on some parameter of the illumination. However, the known designs share common efficiency problems and today’s plasmonic polarization dichroic lenses achieve high contrast dichroism in small areas on the order of the SPP wavelength which poses severe limitation on the application of such lenses with existing detectors. The presented design achieves high contrast circular dichroism inside a large area independent of the SPP wavelength allowing seamless integration with actual detectors. 

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COM-1679: Resistive GP-SIMD

 

The interactions between multiple parallel processors incur performance and power overheads. These overheads are partly a result of data synchronization, entailing exchange between a sequential core and the other cores at the commencement and conclusion of a concurrent section of the workload. While cycles lost on data exchange may be hidden, the power consumption spent on such exchange remains and may significantly reduce the power efficiency of the overall system. GP-SIMD is a novel, hybrid general purpose SIMD computer architecture that resolves the issue of synchronization by in-memory computing, through combining data storage and massively parallel processing.

 

 

 

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COM-1712: Reverse Engineering of a Digital VLSI Circuit using Embedded Scan Chains

Very-large-scale integration (VLSI) is the process of creating an integrated circuit by combining thousands of transistors into a single chip.  The reverse engineering of a VLSI device is a two-stage process- extraction of a circuit description from the physical device followed by behavioral model extraction from the circuit description. The first stage involves a sequence of invasive techniques (packaging removal, de-layering, nanoscale imaging etc.) which can be costly and complex. This new non-invasive method enables extraction using simple and inexpensive equipment, such as FPGA board and a computer.

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COM-1744: Virtual delivery of temperature and moisture sensation- Quokka device

Virtual and augmented reality (V/AR) compose a large part of developing technologies in fields such as medicine, gaming and communication.  The basis of V/AR is sensory stimuli, the ability to experience something through human senses. Currently, visual & auditory stimuli are well developed in contrast to haptics (touch). This new development, Quokka, aims to control the temperature of a local area on human skin using thermoelectricity and peltier elements (two inter-connected metal sheets). When electricity passes through the connectors, the plates change their temperature according to the direction of the current, and this change is felt on the skin.

 

 

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COM-1753: Bundle adjustment with feature orientation and scale (BAFOS)

In many navigation and augmented reality platforms, a camera (or robot) operating in unfamiliar environments is required to accurately estimate the layout of the surroundings. Due to estimation errors, the accuracy of the current methods is compromised. This solution aims to improve estimation accuracy by merging two existing methods. It uses image feature scale and orientation information to formulate constraints which are incorporated into bundle adjustment optimization, resulting in a more accurate depiction of the surroundings.

 

 

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COM-1797: Localization of a moving device using coded light sources

Positional localization aims to track the position and orientation of an object, device or person with very high accuracy, according to a global positioning system. This is useful in numerous applications such as user tracking in Virtual/Augmented Reality, navigation for warehouse robots and autonomous vehicle navigation. The aim of this invention is to carry out this localization effectively across multiple devices, while requiring minimal hardware setup.  It determines the location and orientation of a mobile tracking and processing unit (Tracker) inside a calibrated environment using flashing beacons (Flashers).

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CTT-0739: Medical scaffold, methods of fabrication and uses thereof

The present invention is a method for manufacturing medical scaffolds and their uses in bone repair, and in dental and orthopedic surgeries. The scaffolds are composed of electrospun nanofibers that have a continuous or stepwise gradient of porosity, and an average pore size and weight per volume. The electrospun scaffold has a 3D structure of non-woven uniform, randomly oriented nanofibers with a diameter of 300-500 nm. The combination of the culture of osteogenic cells with an electrospun 3D scaffold provides an in-vitro system that simulates the natural 3D environment capable of supporting bone repair. Note: available for commercialization for applications from the neck down. Read more...

CTT-0744: Natural acellularized cardiac extracellular matrix for tissue engineering

This invention is a cleaning procedure that results in a natural heart-derived cardiac ECM (extracellular matrix) scaffold for cardiac tissue engineering. A natural animal acellularized cardiac ECM as described by the invention is the most suitable scaffold for cardiac tissue engineering: due to the acellularization process it does not evoke an immune response, yet it retains its original properties. The produced scaffolds were shown (in-vitro) to support cultures of muscles as well as embryonic stem cell-driven cardiac myocytes. This technology may be used for various purposes in the field of cardiac tissue engineering such as cell support, tissue replacement and tissue remodeling. Read more...

CTT-0838: Mesoscale bioactive 3D electrospun scaffold for bone repair

The present invention relates to a 3D cubic mesoscale electrospun fibrous scaffold, suitable for implantation in defective bone. The new technology offers nanoscale fibers (PCL) with embedded hydroxyapatite (HA) particles. The combination of electrospun fibers at the nanometric scale and larger mesoscale HA particles imitates the natural structure of bone matrix. This mesoscale scaffold, combined with ceramics and growth factors, constitutes the optimal scaffold to support proliferation and osteogenic differentiation as well as vascularization. It provides a promising surgical tool for bone tissue engineering for many clinical aspects of orthopedic, cranio-maxillofacial and dental applications. Read more...

CTT-0895: 3D vascularized pancreatic islets - for islets transplantation

The present invention provides an advanced tissue-engineering technique for the development of 3D co-culture systems that reconstruct vascularization of pancreatic tissue ex-vivo. In this novel engineered 3D pancreatic model, isolated pancreatic islets can be co-cultured with endothelial cells. The endothelial cells organize into 3D tubes throughout the engineered construct and form vascular network-like structures resembling in-vivo vasculature. This presence of endothelial cells forming 3D vessel-like structures was found to be critical for islet survival. This model can provide an important tool for the therapeutic transplantation of islets, greatly increasing the success of the procedure. Read more...

DDL-1022: Nanoencapsulation of chemotherapeutic and other drugs in beta-casein micelles

Ideally, all drugs could be taken orally at home, optimizing patient response to treatment, treatment costs and patient quality of life. However, the hydrophobic nature of some drugs, especially chemotherapeutic ones, has prevented us from reaching this ideal situation. In this invention beta-casein (and other casein molecules) micelles are used to encapsulate hydrophobic chemotherapeutic drugs, enabling their oral uptake. These preparations may, of course, be further coated with materials that make them gastrointestinal tract site specific, as in targeted chemotherapy. Contact us...

DDL-1074: Compositions and methods for drug delivery

The present invention is of a hydrogel containing an immobilized, naturally-occurring protein drug carrier which may be used for sustained or controlled drug delivery applications. This hydrogel matrix can also be made to be biodegradable. Following this concept, a photopolymerizable hybrid hydrogel was developed, made of poly-ethyleneglycol conjugated to PEGylated albumin for affinity based drug delivery and tissue engineering applications. Contact us...

DDL-1160: OAK cochleates: Method and composition for a delivery platform

Cochleate structures are essential in drug delivery field and may be used as adjuvants. The current invention suggests the formation of cochleates from oligy-acyl-lysine (OAK) compound. The modified OAK may have favorable properties with regard to cost of production, lack of toxicity, stability and size. Contact us...

DDL-1161: Cell-derived liposomes for drug delivery

A major challenge facing cancer therapy is achieving specific cytotoxic effect towards cancer cells while sparing the healthy ones. This invention describes the development of an innovative targeted system for cancer therapy based on mesanchymal stem cell (MSC) derived liposomes. The engineered liposome may contain variety of anti-cancer or cytotoxin compounds which will be released directly into the cancer cells. Contact us...

DDL-1279: Anti-nematode agents

A new fusion method developed by Technion researchers depends on the expression of a certain glycoprotein of nematode origin in the membranes of both fusion partners. The new method for biological, protein mediated, cell to cell and virus to cell fusion can be used for targeting anthelmintics in a nematode specific manner. The homotypic character of the fusion may have many applications in the medical and research fields.

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DDL-1397: Polysaccharide-extracellular-matrix encapsulation for cell and drug delivery

Microencapsulation of cells for cell and drug delivery allows therapeutic products to be delivered to physiological targets to help restore lost function. Our invention suggests using Hydrogel-based polysaccharide-extracellular-matrix (ECM) cell capsules as a system for drug delivery. The novel system of adding ECM to the encapsulation allows regulation of relevant cell activities and secretion of drugs.

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DDL-1454: A new drug and gene delivery system to the brain

Though the brain has relatively high blood flow, it remains one of the least accessible organs for drug delivery due to the blood-brain barrier (BBB) and cerebrospinal fluid barrier, which separate the brain from its blood supply and control the movement of compounds in and out of the brain. Our invention consists of nano-machines composed of liposomes that deliver pharmacological compounds through the BBB to specific subcellular targets in the brain, allowing efficient treatment of various neurodegenerative diseases and brain damage from brain trauma. Contact us...

DIA-1109: Diagnosis and immunotherapy based on analysis of soluble MHC-peptide antigens

The ssHLA- serum-soluble HLA molecules are found in high levels in the serum of humans afflicted with viral infections, autoimmune diseases, different types of cancers and in acute rejection after allotransplantation. This new discovery serves as an excellent prognostic tool for early detection of cancer as well as therapeutic targets and vaccine.

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DIA-1121: Hand-held probe for in-vivo tooth electron spin resonance dosimetry

Nowadays when the risk of exposure to doses of ionizing radiation arises, there is an ongoing need for a simple, inexpensive and accurate detecting device for radiation exposure dosage. The new technique based on electron spin resonance (ESR) measures the absorbed radiation in human tooth enamel. It is perhaps the only such method which can differentiate among dosage sufficiently for classifying individuals that has been exposed. Contact us...

DIA-1522: A microfluidic device for detection of genetic sequences

This invention presents a detection method by of genetic sequences isotachophoresis (ITP) in a microfluidic device. These specific nucleic acids sequences are coupled to fluorescently labeled peptide nucleic acids (PNA). The combination of ITP and the fluorescently labelled PNA enables direct detection of target nucleic acids while eliminating the background fluorescence noise that plagues existing methods. The invention is useful in applications where profiling of specific nucleic acid sequences are required, including medical diagnostics, medical and biological research, food and water safety, and forensics.
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DIA-1567: Microfluidic biosensor chip for accelerated reactions on a surface

The sensitivity of most current surface biosensors is fundamentally limited by the rate at which target molecules bind, particularly at low concentrations. As a result, there is a growing need for methods that significantly accelerate reaction rates and lower detection time. The invention presents a reusable microfluidic chip for the detection of infectious diseases in bodily fluids, water and food.  The reaction surface is immobilized on magnetic beads that are labeled with specific capture probes.  

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DRS-0606: Immune deception for treatment of cancer

In the field of oncology, tumor cells have developed sophisticated strategies to escape immune effector mechanisms. One of the well-known escape mechanisms is using the down regulation of MHC class I molecules, which are the antigens recognized by the immune system cells. This invention presents a new recombinant molecule that binds to cancer cells, making them detectable by immune system cells. This new discovery may open the way for the development of new immunotherapeutic strategies.

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DRS-0655: An antibody fragment capable of modulating multidrug resistance

The present invention relates to an antibody fragment capable of binding to P-glycoprotein associated with multidrug resistant (MDR) cells. The present invention also relates to compositions and methods utilizing such an antibody fragment for inhibiting drug efflux activity in MDR cancer cells. Cancer chemotherapy often fails due to the development of acquired or intrinsic resistance in cancerous cells. A key mechanism of MDR is the overexpression of an energy-dependant efflux pump, known as the multidrug transporter. The present invention demonstrates an antibody that selectively reacts with Pgp-overexpressing cells and is, therefore, an effective inhibitor of drug-efflux activity in multi-drug resistant cells. Read more...

DRS-0673: Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes

Neomycin B is an important antibiotic, commonly used as a food-additive for agricultural purposes. As a result of antibiotic formulations having been used for several decades, resistance to antibiotics has been evolving. The present invention is a Neomycin B that has been modified by the addition of one extra sugar ring. This modification has been shown to both enhance its antibacterial activity against pathogenic bacterial strains and to produce a significant decline in bacterial resistance. The compounds are also active against Bacillus anthracis (anthrax) and are able to inhibit the proteolytic activity of its lethal factor. Read more...

DRS-0764: Methods for treatment of renal failure

Rasagiline is an approved anti-parkinson drug in Europe and Israel. The present invention describes in-vivo experiments demonstrating the improvement in function of hypoperfused as well as normal kidneys pretreated with Rasagiline and its derivatives. Rasagiline derivatives produce significant diuretic and natriuretic responses in association with increased GFR in rats with CHF as well as induce diuretic and natriuretic responses accompanied by improved GFR in the ischemic kidney. It is proposed that this derivative can be used for the treatment of acute and chronic kidney failure. Read more...

DRS-0855: Heterocyclic derivatives in pharmaceutical compositions

In this invention a new compound, a ligand to the peripheral-type benzodiazepine receptor (PBR), is introduced. The PBR-ligand attachment induces anti-apoptotic activity, which is of extreme value in neurodegenerative diseases and traumatic brain damage. Traumatic brain injury is the leading cause of disability in individuals below the age of 40.

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DRS-0932: Novel antimicrobial agents

Over the past decades, advancement in the field of antimicrobial agents had reduced dramatically illness and death due to infectious diseases. However, almost all the prominent infection causing bacterial strains have developed resistance to antibiotics. The present invention relates to novel antimicrobial agents (polymers) designed for exertion of antimicrobial activity while being stable, non-toxic and avoiding development of resistant strains. Contact us...

DRS-0934: Metallocorroles for fighting atherosclerosis and high blood cholesterol levels

Cardiovascular disease and stroke resulting from atherosclerosis might be decreased by using new substances such as metallocorroles, which effectively reduce cholesterol levels and LDL oxidation, thereby slowing and possibly preventing the formation of atheromatous plaques.

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DRS-0938: Reduction of biological injury induced by tobacco related materials

MPTP and/or TSPO have been previously correlated with various pathologies. However, they have never been correlated with the biological injury induced by tobacco products such as cigarette smoke (CS), nor has it been suggested that MPTP/TSPO related drugs/ligands be used to avoid such pathologies. Initial results of both in-vivo and in-vitro experiments showed that CS induced a significant alteration in the specific binding capacity of TSPO, which may be related to the pathogenic pathways leading to various CS induced pathologies such as cancer, aerodigestive and lung diseases such as COPD, cardiovascular diseases, oral periodontitis and many others.

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DRS-0972: Controlling the reactivity of immune cell populations against cancer

Tumor infiltrating lymphocytes (TILs) form immune populations with potential reactivity against melanoma. The degree of reactivity varies considerably among different TIL populations but the underlying network that governs the reactivity is poorly understood. The inventors were able to extract a simple set of subpopulation composition-based rules that explain reactivity to a large extent. Guided by the rules, they were able to restore anti-melanoma reactivity of nonreactive TILs by rational depletion and enrichment of selected subpopulations. This invention describes a generic approach for the prediction, understanding and control of a cell mixture function.

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DRS-1006: OAKs: Novel library of antibiotics that mimic host defense peptides

In this invention a novel library of peptides that mimics host-defense peptides was created. The peptides form a new family of antibiotics with new mechanisms of action that render resistant bacteria susceptible again. Read more...

DRS-1019: Corroles for chronic, systemic, and neurodegenerative diseases

Treatment of neurodegenerative disorders, such as Huntington’s disease and amyotrophic lateral sclerosis (ALS), as well as disorders such as diabetes, has been frustrated by the shortcomings of the available symptomatic drugs. These drugs are incapable of slowing down the progression of the disease and neuronal degeneration. Ongoing research has clearly indicated that therapies aimed at blocking oxidative processes involving reactive oxygen species (ROS) and nitric oxide (NO) production may delay the progression of the disease. Metallocorroles designed in the invention have demonstrated remarkable antioxidant properties and have been proposed as an ingested medicine for the above stated conditions in addition to the previous work on atherosclerosis. Read more...

DRS-1049: Novel fluoroquinolone-aminoglycoside hybrid antibiotics

Bacterial resistance to antibiotics plays a major role in today’s medical world. A series of new hybrid antibiotics containing fluoroquinolone and aminoglycoside antibiotics were designed, synthesized and their antibacterial activities were determined. This combination yielded a new superior antibiotic: very potent on the one hand and resistant to bacterial resistance enzymes on the other.

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DRS-1300: Combinations of corroles and statins

High blood cholesterol level is a main and well established risk factor for the development of cardiovascular disease. Statins, inhibitors of cholesterol biosynthesis, are the leading drugs for reducing cholesterol levels and the most prescribed pharmaceuticals worldwide. We have created synthetic molecules, corroles, which are catalytic antioxidants that also effectively inhibit cholesterol biosynthesis. Furthermore, the combination of corroles and statins is highly synergistic, implying such a co-therapy as extremely useful for treating cardiovascular disease and other diseases related to hypercholesterolemia.

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DRS-1315: Imidazoacridinoneand sunitinib-dependent lysosomal photodestruction

Multidrug resistance (MDR) poses major obstacle for cancer treatment. Thus, developing novel strategies to overcome MDR is of a paramount clinical significance. The present invention proposes anticancer therapeutics and describes a new strategy to overcome MDR, based upon lysosomal sequestration of cytotoxic agents of the imidazoacridinones (IAs) family and consequent lysosomal photodestruction by illumination.

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DRS-1457: Corroles for treatment of diseases

Corroles are synthetic, porphyrin molecules that can act as catalytic antioxidants. Corrole derivatives can be used for lowering the probability of developing chronic kidney disease, especially diabetic nephropathy, for which there are currently no approved therapeutic drugs. Additionally, they can act as catalytic oxidants which can be used as oral or intravenous treatment for reducing the chances of developing cataracts, especially in diabetic patients.

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ENE-0980: Fan and ducted-fan performance enhancements

The presented invention pertains to personal, industrial and automotive cooling, ventilation, vacuuming and dust removal, inflating, etc. Other applications are computer component cooling, propellant for air vehicles and for airboats, air-cushion vehicles, airships and model aircraft. The invention suggests using a dielectric barrier discharge plasma actuation in a new method in order to significantly improve the function of the applications mentioned above, and possibly decrease energy consumption wherever it is implemented.

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ENE-1017: Solar voltage amplifier

Unlike PV cells that are standalone systems designed to produce current, the technology proposed here enables the addition of solar energy harvesting to any existing electrical system by connecting it in series. This novel concept of producing a solar voltage amplifier is applicable to both small and large scale operations. It can be designed as an “inverse lamp” for small appliances for private use or for large scale power plants capable of creating vast amounts of electricity. The system conceived in the Technion for solar energy conversion consists of an absorbing medium. Its population is inverted in a broad range of frequencies, corresponding to the solar spectrum. Once illuminated, the population of the majority of the energy states may be inversed and as a result, according to the PASER concept, the medium may act as a negative resistance component. In other words, power is transferred from the solar radiation to the electrons via the medium. This can be visualized as a voltage amplifier. Read more...

ENE-1053: System for cooling, dehumidification and air conditioning

Global warming, has led to an increase in air conditioning demand not only in hot and humid climates such as in Mediterranean countries, but also in European countries with no air conditioning tradition. Electric utilities have their peak loads in hot summer days, and are often barely capable of meeting the demand, struggling with brown-out situations. With suitable technology, solar cooling can help alleviate, if not eliminate the problem. We developed a technology that is capable of using industrial waste heat or low-grade solar heat from low-cost flat plate collectors as their source of power, and have the potential to provide both cooling and dehumidification, as required by the load.

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ENE-1167: Autonomous natural gas reformer for on-demand hydrogen generation

The demand for hydrogen fuel cells is growing and consequently, the need for hydrogen is growing as well. We offer a natural gas autonomous membrane reformer for onsite and on-demand small-scale hydrogen production to facilitate hydrogen fuel-cell stack power generation. A working prototype of this compact, efficient and thermally independent unit has shown much promise for autonomous generation of ultra-pure hydrogen from natural gas. 

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ENE-1229: Vertical axis wind turbine control

Dynamic stall on vertical axis wind turbines (VAWTs) causes a significant decrease in energy and possibly detrimental oscillatory loads. Our invention implements control of dynamic stall by steady or oscillatory perturbations. The invention can significantly improve energy production of VAWTs, decrease the damaging oscillatory loads, reduce working-point (blade-speed to wind-speed ratio), and self-start the turbine. Contact us...

ENE-1239: Dry power: Harnessing energy from evaporation

Energy, normally in the form of electricity, is a basic requirement for the modern life-style and the search for "green" energy is a major focus today. The invention provides a novel eco-friendly mechanism and device for producing mechanical power, in the form of pressure oscillations (sound waves). The energy source for driving these self-sustained oscillations is the pressure change of dry air, induced by evaporation within an acoustic resonator. The pressure oscillations may be coupled to an external load, to be concurrently converted into electricity by means of a linear motor or, alternatively, be used to drive a thermo-acoustic heat pump producing heating/cooling, as required.

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ENE-1328: Light trapping in ultrathin film solar cells

This invention offers a solution for boosting the light absorption efficiency of extremely thin photoactive layers placed on top of a reflective layer (mirror). With the photoactive layer’s thickness designed to afford it anti-reflective properties, it can be reduced to a thickness of nanometers - saving up to 95% of the materials cost for 2nd generation thin film PV cells, such as Cadmium telluride (CdTe) and copper indium gallium selenide (CIGS). This light trapping design can also be used for efficient conversion and storage of solar energy in the form of hydrogen using ultrathin film photoelectrodes for water splitting (photoelectrolysis).

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ENE-1436: Entropy driven up conversion

We demonstrate a new method for inducing effective high temperature on the surface while maintaining low bulk temperature. Based on this concept we demonstrate 10-fold up-conversion of optical frequency at 10% efficiency, much higher than ever reported. Additionally, the effective high surface temperature is useful for thermal and chemical processes, where the bulk temperature must remain cooled.

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ENG-1260: High-speed OFDM-based passive optical access network

As the demand for greater data throughputs is increasing exponentially, optical access networks are increasingly providing a key solution, with extended band-width, long-reach and long-term operational cost. The first generation of Passive Optical Networks (PON) is currently deployed around the globe, but demands for greater data-rates are expected to exceed far beyond the available throughput of current technology. There is an increasingly growing interest in cost-effective technology to improve spectral efficiency of optical networks while allowing flexible bandwidth allocation between users. The presented PON solution significantly reduces optical network unit (ONU) complexity by reducing ONU sampling rates. This solution enables low-cost home premises equipment at very high-performance rates, with flexible bandwidth allocation, and enables multiple ONUs to be supported over long distances.

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ENG-1277: Sub-Nyquist sampling of short pulses

Current methods of pulse sampling are limited in their ability to sample efficiently when both the pulse shapes and their locations are unknown, treating the multi-pulse signals like any other time-limited signal, not taking sparseness into account, and collecting unnecessary samples. The presented technology allows for recovery of multi-pulse signals at sub-Nyquist rates with high precision from a small number of measurements without the need for any prior knowledge of position and shape. This system can be applied to many fields, including radar, ultrasound, communication and medical imaging signals.
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ENG-1326: Avalanche photodiode and a method for sensing photons

Highly demanding photonic applications require the acquisition of images at very low light-level conditions and at high speed. Only Geiger-mode CMOS imagers in which the sensor in each pixel is a single photon avalanche photodiode (SPAD) may meet the requirements for exceptional time resolution and ultimate optical sensitivity. However, despite significant progress, Geiger-mode CMOS imagers are still commercially unavailable. Conventional designs are incapable of achieving high fill factor, high PDE, and low DCR. This innovative design utilizes a completely new method to achieve all of the desired properties for this type of imagery.

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ENG-1345: Sub-band processing with over-sampled filter banks

Critically sampled uniform DFT filter banks are well known in signal processing while oversampled uniform DFT filter banks are less known. In this invention, oversampled filter banks are used in an innovative way to perform nearly perfect multiplex frequency division (FDM) over a broadband contiguous communication spectrum occupying the full band. The banks are capable of synthesizing this spectrum from independent sub channels, each occupying a single frequency sub band, without requiring any spectral guard-bands between the sub bands, i.e., with nearly 100% spectral efficiency. They are also capable of separating the contiguous broadband spectrum (which may also be generated by other methods) into individual sub-channels, near perfectly reconstructing the individual sub channels. The filter banks are structured in a novel way such that the complexity of hardware processing is significantly reduced without compromising performance.

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ENG-1506: Pad printing on rigid and flexible surfaces

This invention relates to the printing of micrometer or nanometer scale patterns using a modified pad printing apparatus. The device uses a printing plate prepared from a silicon wafer and a printing pad combined from one rubber standard pad and one Polydimethylsiloxane (PDMS)  membrane or stamp as a sub pad. This invention improves upon the current methods by offering a more cost efficient solution without the limitation of optical diffraction or rubber pad abrasion. The simplicity of this improved method allows for larger volume productions that may be relevant by pad printing manufacturers, solar cell manufactures, EMI/RFI optical object shielding, and more. 

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ENG-1545: Self-adjustable lenses for presbyopia

Multifocal lenses can be expensive, cause distortions, limit the field of view, and are only set to deal with specific distances. The presented method shows how to design adjustable lenses for presbyopia correction and to create the actual product. The design method includes optimizing the optical element in two or more relative positions for many gaze directions in each fixed position of the lenses. The final product will be lenses consisting of two such optical elements and a dedicated frame that provides good vision at an acceptable visual window without jumps and at a lower cost than traditional solutions.

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ENG-1599: Dynamically balanced folded-beam suspensions

In microelectromechanical (MEMS) devices, moving parts are suspended on flexures which are constructed from flexible beams to allow movement in a single direction only and as elastic springs. Due to issues associated with abrasion, most MEMS devices cannot incorporate hinges and sliders. The most prevalent suspension in electrostatic actuators and sensors is the folded-beam suspension, but the system response of this suspension is nonlinear. The presented method implements a deeper understanding of this non-linearity to produce suspensions which perform linearly at a specific frequency. All MEMS devices which include an electrostatic resonator (e.g. MEMS gyros, MEMS clocks, chemical and biological sensors) may benefit from a spring with a stiffness that does not change with vibration amplitude.

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ENG-1636: Cold Plasma Source for Medical Treatment

Over the last decade, a significant interest has developed in applications of the dielectric barrier discharge (DBD) for generation of “cold” plasma (low-ionized and non-thermal atmospheric plasma) which can be used for different applications in medicine and industry. However, existing designs of cold plasma sources cannot be implemented for in-vivo treatment of patients, they have low efficiency of plasma generation, and they are hazardous to patients through electromagnetic radiation and electrical breakdown. The presented technology allows for the development of a reliable and efficient source of cold plasma which can be used for the treatment of cancer and other diseases, as well as blood corrugation and tissue sterilization.

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ENG-1650: Optical Very Large Scale Integration [O-VSLI] by Optical Tweezing of Fluids

Many biological and chemical inspections and analyses can be more easily performed inside small water or hydro-gel droplets, created using ultrasound, light and capillary waves. However, these droplets tend to evaporate too quickly. Current methods include controlling humidity or evaporation or utilizing glass micro-capillaries. However, these can be complex, expensive and slow, while creating other problems at the same time. The presented solution connects the micro-droplet to a reservoir which compensates for evaporation, making the droplet self-sustaining. This liquid micro device will technologically enable liquids as materials for optical devices with advantages of interface smoothness, high transparency and bio-compatibility that are unique to fluids.

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ENG-1682: Field effect transistor structure

A novel transistor design is proposed, the statistical transistor, which through a single additive step can overcome the problems associated with the crystals grain boundaries and the accompanying non-uniformity. Conducting islands are deposited on or below an assembly of organic crystals, thereafter a continuous electronic path is formed and the device operates as single crystal transistor. The conducting island pattern does not require any alignment and hence is compatible with printing and roll-to-roll manufacturing. 

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ENG-1702: Multimodal Annular Ring GNSS ADS Antenna

 

There are many approaches to determining the attitude (orientation in 3D space) or direction (2D space) of an object. However, known solutions, such as gyroscopes and interferometry between GPS antennas, compromise between the compactness of the system, accuracy of the measurements, poll rate and cost. The proposed antenna is a low-cost, relatively compact solution, requiring about half the space for equivalent accuracy when compared to interferometric systems. This invention provides both attitude determination as well as true-north determination for applications that are space limited and require instantaneous accuracy.

 

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ENG-1764: Acoustically enhanced heat exchangers

Many systems require heat to be either added or dissipated towards maintaining their operability and efficiency. The change in temperature is provided by a heat exchanger, connecting two streams that have a thermal potential difference. Due to form factor limitations associated with many size-restrained applications, the state of the art is advancing towards compact designs. This forms the basis towards higher performance and efficiency heat exchangers – enabling more heat transfer for the same size machine. We present here a method for obtaining a significant increase in heat transfer by exciting the flow channels with sound waves that are in tune with the system acoustic resonances. Enhanced heat transfer may be achieved with existing or next generation CHEs designs with minimal additional pressure drop.

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MAE-0593: Space-variant subwavelength polarization grating

Laterally-varying polarizers have found application in a variety of fields including material processing, tight focusing, polarimetry, particle trapping, particle acceleration and development of optical computers. However, with conventional polarizers, the transmission axes vary laterally in a discontinuous manner degrading the optical efficiency of the polarizer. This invention uses computer-generated space-variant subwavelength dielectric metal wire gratings for the formation of radially and azimuthally polarized light from a polarizer whose transmission axis varies laterally in a truly continuous manner. By correctly determining the direction, period and depth of the grating, any desired continuous polarization can be obtained.

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MAE-0614: Space-variant subwavelength dielectric grating

Polarization measurements are important for a large range of applications such as ellipsometry, bio-imaging, imaging polarimetry and optical communications. This method enables the use of computer-generated space-variant subwavelength dielectric gratings for the formation of radially and azimuthally polarized light. By correctly determining the direction, period and depth of the grating, any desired continuous polarization can be obtained. Furthermore the continuity of our grating ensures the continuity of the transmitted field, thus suppressing diffraction effects that may rise from discontinuity. Our gratings are compact, lightweight, flexible in design and have high transmission efficiency. The gratings have been used in the laboratory to achieve experimental measurements of polarized and partially polarized CO2 laser radiation at a wavelength of 10.6 μm.

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MAE-0632: Increased life for gas filters using acoustic fields

Gas filters clog over time: the captured particles gradually build up in layers and clog the filter. This leads to a pressure drop across the filter, which results in increased energy consumption. Common methods of filter cleaning require mechanical vibration, air jets or reverse flow. However, vibration increases filter material wear, and reverse flow methods add complexity and significantly increase price. Our method uses sound waves, in a simple and low cost setup, to extend the service life of gas filters by up to threefold. Read more...

MAE-0730: Active detection of asymmetry in turbo machinery via asynchronous excitation

High-speed rotors are sensitive to cracks and small deformations which can cause billions of dollars in damages and injuries every year. This invention is the first to accurately identify small cracks and similar deformations in rotating bodies while the machine is running and without requiring disassembly of the machine.

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MAE-0735: Electro-optical and all-optical beam steering

Since its early prediction, self-deflection of optical beams has been considered one of the most exciting manifestations of nonlinear optics. Self-deflection occurs when a single beam propagates in a non-linear medium, develops an asymmetric profile and consequently curves and carves its own trajectory which is determined by the beam intensity. Applications for self-deflected beams range from optical interconnects, laser printers and optical scanners to low-cost, low-weight and compact optical limiters but until now, progress with beam self-deflection has been limited. This invention is able to achieve deflections 12 times greater than what has previously been achieved while operating at powers hundreds of time lower than conventional devices, offering a large step forward in this field.

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MAE-0763: Space-variant polarization manipulation of a thermal emission

This technology offers a method for space-variant polarization manipulation of enhanced non-directional thermal emission in a narrow spectral peak. This can be used to create thermal sources, for decoding thermal coding or for thermal management. The polarization is accomplished by irradiating non-directional thermal emission on a subwavelength grating supporting surface phonon-polariton or surface plasmon-polariton and discretely controlling the local orientation of the grating.

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MAE-0791: Autonomous control scheme for unmanned aerial vehicle flocks

The use of armed unmanned aerial vehicles (UAVs) is on the rise. When several crafts are sent on a mission, their communications bandwidth requirements make them vulnerable. Our fully-autonomous management scheme for UAV flocks can overcome this weakness.

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MAE-0862: Highly sensitive, real-time structural monitoring

Structures such as aircraft, ships and bridges rely on rivets and joints which are constantly undergoing wear and therefore must be continuously examined. Our technology aims at monitoring the health of critical joints by utilizing wave components previously considered unusable noise. Read more...

MAE-0995: Piezoelectric-ferroelectric stack actuator and shape control algorithm

Piezoelectric stack actuators are a common choice for micro- and nano-positioning systems. However, they are limited in terms of travel range (stroke). Our advanced piezoelectric-ferroelectric actuator has a travel range-to-length ratio up to six times greater than traditional piezoelectric stack actuators. Furthermore, the active layers in the advanced stack are controlled separately or in groups and are assigned with either a de-poled or a fully polarized domain state. This feature minimizes vibrations, allows for a controllable and extended travel range, and ensures that the nano-scale positioning accuracy is maintained. Applications vary from microscopy to fuel injectors or from digital cameras to structural systems.

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MAE-1046: Tactile feedback mechanism

This invention uses local changes in pH caused by electrical current in a solution to create local topographical changes on a surface. Common applications include Braille displays and tactile feedback for touch-screen displays.

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MAE-1057: Self balancing motorcycle

Motorcycle riding has always been a dangerous and attention-demanding activity, especially when compared to driving cars and other enclosed vehicles. The motorcycle’s unstable nature makes it vulnerable to road hazards and emergency situations, and the consequences of accidents can be harsh. Our technology enables a motorcycle to balance itself, allowing for major advances in road safety and autonomous robotics.

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MAE-1112: Dilute nitride-based quantum well infrared photodetector

Optoelectronic devices operating in the near infrared (NIR) to mid infrared (MIR) spectral range offer a diversity of applications ranging from telecommunications to chemical sensors for pollution detection, chemical forensics, chemical and biological warfare, industrial process monitoring, night vision and even medical diagnostics. However, conventional material systems and IR-detectors do not effectively meet these optical range needs. This invention offers a new type of IR-device in the NIR to MIR range, based on optical transitions to foreign atoms which when inserted into standard active layers in quantum well infrared photodetector (QWIP) devices, affect electronic states. Single element devices operating at ~1.5 μm at RT, that were fabricated and tested in our lab, demonstrate high responsivity of ~20 A/W, and signal gain of ~1000 (which is not relevant for the dark current and dark current noise). This new type of device may potentially enable single photon detection at the NIR range.

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MAE-1127: Combustion chamber discharging condensed mass

Rocket-type thrusters produce thrust by expelling a jet of gases through an exhaust nozzle. This invention is designed to attain much larger impulse and impact efficiency for the same amount of propellant and chemical energy by discharging condensed mass (solid mass, liquid gel or powder) through an exhaust tube instead of combustion gases. This augmentation of the overall impulse results in better utilization of propellant energy providing increased efficiency and better performance for space vehicle and missile propulsion and control. This is ideal for applications that require a large impulse from a relatively small amount of propellant.

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MAE-1140: Incorporating nitrogen in InAsN/GaAs quantum

In recent years, the dilute nitride alloys (III-V-N) has been the subject of intense theoretical and experimental research effort because of their ability for band gap and band offset engineering, and thus have potential for a wide range of optoelectronic device applications. By optimizing the nitrogen content, the lattice constant and band-gap energy can be varied over a wide range tailoring the material’s properties to a specific application, such as near-infrared (IR) lasers and quantum-well IR photo detector (QWIP) devices. However, the growth of high-indium-content dilute nitrides using metal organic chemical vapor deposition (MOCVD), which is important for such applications, is not straightforward. This laboratory-tested method overcomes this difficulty and allows for the manufacture of high-quality structures tailor-made for specific optical communication devices.

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MAE-1216: Tuneable XBn and nBn and PV infrared detectors

The ability to fine-tune the band gap of infrared (IR) detectors allows for multispectral imaging, which has many commercial military and civilian applications. However, conventional manufacturing methods are extremely limited in this field. This invention utilizes well-known and well-studied properties of dilute nitrides to utilize PV, nBn and XBn structures and their reduced working temperatures, to retain control over the bandgap energy of the III-V-N semiconductor active layer through control over its composition retaining the lattice-matching constraints. This laboratory proven method can pave the way for lattice-matched, compositionally tunable band gap active layers for infrared detectors with a cut-off wavelength between 3-5 microns or more.

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MAE-1220: New active layer for GaAs-based lasers

Great efforts have been made toward achieving 1.3-1.55 μm emission from high performance GaAs-based lasers for use in a wide range of commercial optoelectronic devices. Research has shown that controlling the band-offset and not just the bandgap is essential in order to optimize the laser performance. This lab-proven technology succeeds in creating a bi-layer structure that can be used as an active layer for a near infrared (NIR) laser. The layer demonstrates high gain, low transparency carrier density, acts as an almost equal barrier for electrons and holes and an equal lifetime for thermal escape-all necessary properties for creation of an optimized NIR GaAs laser that can outperform existing commercial devices.

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MAE-1369: Bio-inspired control of legged locomotion enhanced using minimal feedback

Current control methods for biped locomotion work mostly on horizontal planes, are relatively slow and non-human like. In order to be robust, these methods require large computation resources, as well as accurate sensors and actuators. The presented technology is a novel method that produces a more energy efficient walk over a wider range of slopes than available solutions. The invention is biologically inspired, thus, aside from contributing to the development of humanoid robots, it can help with robot assisted patient rehabilitation and walking platforms (exoskeletons), and with the improvement of orthotic devices. Read more...

MAE-1411: Selectively stiffened flexures for motion conversion mechanisms

Motion conversion in micro-electro-mechanical systems (MEMS) requires specially fabricated mechanisms that currently are not able to be mass produced but rather custom hand-made fabrication for each device is required. The technology presented is a novel dual-height design that is easier to fabricate using standard mass-fabrication technology. The technology can be used for optical MEMS applications as well as other mechanical mechanisms which require motion conversion.

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MAE-1447: A miniature cryocooler activated by piezoelectric elements in resonance

Rotary and conventional linear compressors tend to have higher maintenance requirements reducing machine lifetime. This invention introduces a miniature cryogenic cryocooler, based on a linear piezoelectric compressor that offers superior efficiency, power density and speed of operation in comparison to other available compression systems. This concept of the direct gas compression effectively employs a piezoelectric actuator in a Stirling-type-cryocooler compressor operating at low-frequency resonance. The high efficiency together with a no-moving-parts design make the double piston piezo compressor a superior alternative for applications requiring long life, reliability and silent operation.

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MAE-1485: ICon - inflated connector

Connecting high density polyethylene tubes in open sea aquaculture cages can be problematic due to the pipes’ flexibility when subjected to the water’s dynamic motion. Other types of rigid clamps or rope-connections cannot both keep the functional relative position of the elements and enable the imposed motion without failure or damage. The presented technology uses inflatable Elastomer cushions with a durable, easy-to-apply skin to hold the elements together, thereby distributing the applied stress. While this type of connection has a unique advantage in dynamic environments, it is a useful and efficient connector for other pipe structures as well.   

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MAE-1513: Direct shape recovery from photometric stereo with shadows

Image reconstruction systems are necessary to interpret complex textures on the surfaces of biological tissues. Other methods have been presented, such as stereo vision systems and active illumination systems. However, these methods are often expensive, require high specialization, or involve complicated additional equipment. The presented endoscopic imaging system uses an uncomplicated light setup and a new computationally efficient theoretical model to provide low-cost, accurate 3D reconstructions of complex textures and surfaces.

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MAE-1530: Mass balancing using tuned parametric excitation

Mass imperfection in rotating elements and machines causes vibration when the speed of rotation reaches critical speed. This has led to the development of mass balancing machines which identify where mass imperfections lie. Current balancing machines are limited in the attainable speeds of rotation, and on-site balancing is risky and expensive. Our innovation attains an equivalent vibration of the element at high speeds of rotation without having to bring the element to such dangerous speeds. After balancing, the machine can safely operate at high speeds of rotation.

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MED-0680: Ion concentration sensor

Ion concentration measurements, particularly pH measurements, are performed routinely in the chemical, biochemical, biomedical and other fields. Also, much effort has been invested in creating a combined ion and image sensors for advanced biotelemetry systems. Conventional ion concentration sensors require readout circuitry to convert an electrical response to values corresponding to the ion concentration in the solution. This circuitry increases the size and complexity of the sensor and increases its power consumption. Furthermore, it also adds limitation to the bandwidth and reduces the stability of the sensor. This sensor can perform simultaneous ion and image sensing without readout circuitry creating a critical device for advanced biotelemetry systems that are energy-efficient, compact and reliable. Read more...

MED-0706: Electronic receptor and its application to controlling biological processes

The present invention aims at gaining electrical control over biological processes, namely, triggering or suppressing a selected biological pathway by an electronic signal presented to the system. The strategy relies on the selection of antibodies that recognize and bind a specific set of nano-scale electrodes biased to a certain voltage configuration. The implications of such an interface are far reaching. One may envision sensors that probe several biological parameters, converting them into electronic signals. Read more...

MED-0835: Fast retinal imaging by parallel projections

The present invention relates to a device and method for fast retinal imaging and extraction of medical parameters from these retinal images. The innovative technology provides an imaging system that takes a single shot of the retina at various depths, obtaining retinal depth information immediately and providing fast information and continuity of data. The expected price of the system should be less than optical coherence tomography systems, and only slightly more than fundus cameras. Read more...

MED-0867: Subwavelength structures for a hollow waveguide

Hollow waveguides present an alternative to solid core fibers in the IR regime where suitable optical materials are scarce. Due to their air core, they can also be used for broad-spectrum high power transmission due to small insertion losses. This makes them suitable for use in industrial or medical applications or for spectroscopic and radiometric measurements. Conventional hollow waveguides rely on multimode operation; however, this technology allows for the excitation of only a single waveguide mode making it well-suited for certain devices like hollow waveguide lasers.

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MED-0939: Cylindrical probe for ex-situ nuclear magnetic resonance spectroscopy

This invention is a new type of ex-situ nuclear magnetic resonance (NMR) probe with spectroscopic capability. NMR, and its descendant, magnetic resonance imaging (MRI) are among the most powerful and versatile analytic and diagnostic methods in science. Current devices suffer from the need to employ large magnets that surround the examined sample/object. The large magnet and the correspondingly large RF coils are a major factor in the complexity and the high cost of NMR and MRI systems. In addition, in many cases the sample cannot be placed inside the bore of the magnet or cannot be moved. The present invention describes a new type of ex-situ NMR probe, which through innovative design, achieves mobile NMR/MRI capability. The achievable spectral resolution is on the order of ~0.5-1 ppm. Read more...

MED-0949: Diagnosis of chronic renal failure and kidney related diseases nose

End-stage renal disease (ESRD) is a debilitating medical condition of chronic kidney failure, which requires intensive and costly treatment through dialysis or transplantation. Early screening and intervention may reduce neuropathy progression and may bring to remission increasing. Our suggested technology may be able to differentiate between “healthy” and “renal failure” breath, which may contribute to the early detection of the disease.

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MED-0971: Non-contact holographic stimulation technology for vision restoration devices

A unique technology for direct optical stimulation of neurons has been developed in the Technion. This Technology could have diverse applications in the field of advanced neurological devices and particularly the development of next-generation vision restoration devices. The new, non-contact method is based on rapid holographic stimulation and enables energy-efficient patterned activation of many neurons with high resolution (single cells) and high light efficiency.

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MED-0991: In-vivo flow-cytometry

In this invention, a method for imaging the cross section of a vessel for detecting the flow of cells using spectrally encoded imaging was developed. This method provides visual information on the scattering particles, including their size, shape, brightness, as well as their location within the vessel. Such information could significantly increase the accuracy of flow cytometry and provide additional capabilities, such as cell sorting and the modification and destruction of specific cells. Potential applications include in-vivo and ex-vivo flow cytometry for industrial and clinical applications. For in-vivo applications, the compact dimensions and simplicity of the probe, which is approximately 20 x 5 x 5 mm in size with no moving parts, could enable endoscopic flow cytometry in various locations in the body. Contact us...

MED-1151: Dispersion-controlled adjustment of imaging plane in spectrally encoded endoscopy

The spectrally encoded endoscopy (SEE) is a new method utilizing a single optical fiber and miniature diffractive optics to encode transverse reflection from a sample. The use of this method dictates the geometry of the focal plane which limits in many applications where the object is in a certain position. The new invention proposes the use of chromatic dispersion management to adjust the depth and angle of the image plane of interferometric SEE.

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MED-1152: Techniques for spectrally encoded endoscopy

We propose a few innovative techniques for spectrally encoded endoscopy. One technique is a method for multiple-channel spectrally encoded endoscopy (MC-SEE), in which the illumination and the collection of optical paths are separated in space. This invention enables a larger depth of field imaging, speckle noise reducing and signals detection of different excitation and emission wavelengths. The other technique, using dispersion, may be effective in optimizing imaging quality and field of view. Contact us...

MED-1227: Multifocal ultrasound and its effect on biological membranes

Ultrasound has been extensively used for imaging for 60 years, and is now being studied towards clinical therapeutic application. Understanding the basic mechanism of its function is critical. Technion Researchers propose a hypothesis whereby ultrasound induces bubble formation in the intra-membrane space in cells, between the two lipid leaflets. Those bubbles accumulate, creating pockets of gas. As the pockets grow, surrounding structures are being pushed. A possible therapeutic application of this discovery is in the field of neurophysiology, where the use of multifocal ultrasound on neural tissues is likely to become essential to future treatment for people who have a major deficiency in their sensory systems, such as blindness or deafness.

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MED-1278: Method for spectral imaging using spectral encoding

Spectrally encoded spectral imaging is potentially useful in many commercial and scientific applications. The improved signal-to-noise-ratio (SNR) and the simplicity of this approach would offer better alternatives to current spectral imaging systems. Our novel invention has simpler optics and hardware compared to the color filter and interferometric approaches, and has improved SNR compared with point and line scanning techniques. Among other exciting applications, spectral imaging through compact endoscopic probes is possible. Contact us...

MED-1285: Manipulation of cells using combined opto-acoustic excitation

The present invention describes targeted and rapid means for reversible mechanical manipulation of individual cells (e.g., activation of excitable cells such as neurons) using the combined, synergistic action of light and ultrasound. This method provides modulation of the individual cell from distance in a selective, reversible, and rapid way and may be used in various applications as neuron stimulation for inner ear prosthesis, retinal prosthesis, implanted pacemaker and more. Contact us...

MED-1299: CMOS ISFET sensitive detector

The present invention relates to a novel device for acidity (pH) or ion concentration measurements. The proposed device is a differential, calibration-free and reference-electrode-free CMOS ISFET with remote sensing antennas. It eliminates the need for costly calibration, provides better stability over time and can be used where minuscule sensors are required, as in in-vivo medical and biomedical applications.

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MED-1303: Damaging cells using nanoparticles and short laser pulses

Currently used anti-cancer treatments are highly toxic to both healthy and cancerous tissues, often leading to patient’s death due to the treatment itself. We suggest novel strategy for the treatment of cancer by targeting cancer cells with carriers conjugated to gold nanospheres and illuminating the cells by short visible laser pulses. It will ensure local tissue damage whilst avoiding massive temperature elevation which may damage healthy tissues. Contact us...

MED-1327: Method for optical stimulation and monitoring of neurons

The present invention outlines a method for creating a novel neural interface based on optically controlling neurons in a cell-containing hydrogel based transparent transplant. The transplantable neural network could be applicable in various fields. One of the fields is CNS tissue engineering, providing a possible treatment for brain injuries, stroke, neurodegenerative diseases and more. Contact us...

MED-1405: Noninvasive imaging of flowing blood cells

This novel method of noninvasive imaging, which allows visualization of the morphology and dynamics of circulating cells, avoids the need to handle specimens and bypasses the need for exogenous labeling of cells, with potentially toxic dyes. Additional advantages include shortened wait-time, portability and the potential to detect early warning signs before severe medical problems develop. Utilized correctly this could shift high-volume routine tests out of the core laboratory and to point-of-care settings. There are many possible applications such as screening and diagnostics as well as new possibilities in clinical research and practice. Contact us...

MED-1639: Exploiting similarity in adjacent slices for fast MRI

Magnetic Resonance Imaging (MRI) has become a well-established medical diagnostic tool for imaging structures within the brain and body of a patient.  There is a fundamental trade-off between image quality and acquisition/scan time, and an urgent need in speeding-up the acquisition of MRI. However, current methods for speeding up image acquisition require extended computational time and high memory usage and often lead to reduced signal-to-noise ratio (SNR) and to image degradation at high speed-up factors. The presented technology utilizes the similarity between slices to speed up the entire acquisition process.  This significant acceleration of MRI scan time with minimum compromise on image quality is expected to bring a paradigm shift reducing the time needed for sedation in children, decrease patient discomfort and increase the availability and accessibility of the MR modality. Moreover, it will allow deeper analysis of various brain activities and time varying processes in fMRI, thanks to the improvement in the temporal resolution in this modality.

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NUT-1076: Addition of prolactin to infant formulas

Breast feeding supports the provision of prolactin, which plays an important role in regulating calcium absorption in mammals during neonatal, and may have other physiological functions as it can be absorbed in the intestine of neonates. The present invention suggests the addition of human prolactin to infant’s formula in a concentration similar to that present in human milk in order to make it more similar to human milk and enjoy the major benefits of prolactin.

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NUT-1293: Beta lactoglobulin based nano complexes as protective nanovehicles for EGCG

The addition of EGCG "as is" to a product results in browning and possible degradation of health benefits.  Though in acid beverages EGCG is somewhat more stable, still it degrades quite quickly and has a bitter and astringent taste. Our novel invention uses beta heat –treated lactoglobulin for nanoencapsulation of EGCG, its protection in various clear and other beverages, and improvement of its sensory properties. 

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NUT-1314: Core-shell nanocapsules for protection of water-insoluble nutraceuticals in clear drinks

With the growing public awareness for healthy nourishment, there is a desire to provide healthy nutraceuticals is by enriching staple foods and popular beverages with these compounds. However, this is a challenge when trying to integrate hydrophobic nutraceuticals in clear drinks. Our invention proposes enriching clear beverages with nutraceuticals using encapsulation-agents made of Maillard reaction based conjugates of natural proteins and polysaccharides. This enables the stabilization and protection of poorly-water soluble nutraceuticals during processing, shelf-life and gastric digestion- and release in the intestine for better absorption.

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NUT-1547: Potato protein nanocapsules for stabilization of compounds in aqueous solution

Enriching foods with hydrophobic bioactive compounds presents a challenge due to their poor water solubility and degradability. This invention proposes using potato protein nanocapsules to solubilize, protect and mask undesired flavors of such hydrophobic bioactive compounds, for application in foods and beverages- particularly clear ones.  Potato protein has appropriate properties, and it provides an added benefit compared to other solutions due to its low cost, GRAS status, applicability in Kosher-Parve foods, label friendliness (“all natural ingredients” claim possible) and non-allergenicity. 

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RES-0870: Electrical control over antibody-antigen binding

Technion inventors have discovered a method to electrically control the binding of an antibody to its antigen. The formation of such bond is highly influenced by surrounding voltage, because the electrical charges of the amino acid’s residues in the antibody protein are affected by it. The method facilitates exquisite control over one of the main interactions responsible for biomolecular recognition, which is a prominent function of the immune system.

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RES-1464: Nano-liter droplet incubation array

This nano-liter droplet incubation array, or "StatDrop," provides a new method of creating single cell analysis arrays. The device is based on a reversed-order loading procedure, which results in an array of indexed stationary droplets with variable chemical composition. The array can support adherent and non-adherent cell cultures. StatDrop's simplicity to operate, minimal use of reagent, and portability make it convenient for uses such as creating multiplexed single cell performance assays for research and diagnostics.

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STM-0613: Differentiated human embryoid cells and a method for producing them

The present invention is a process for obtaining human derived embryoid bodies (hEBs). It is based on the finding that hEBs may be obtained in-vitro from human embryonic stem (hES) cells suspended in a liquid medium. These hEBs contain mesoderm, ectoderm and endoderm cell lineages and may be used as a source of cells of the different lineages. The hEBs can then be used as a source of cells for use in transplantation or inoculation into a human recipient, in order to treat various diseases or disorders, to assist in tissue repair, and to substitute for degenerated tissue. Read more...

STM-0630: In-vitro identification, isolation and differentiation of vasculogenic progenitor cells

The present invention is of a simplified and inexpensive method for the in-vitro identification, isolation and culture of human vasculogenic progenitor cells. The technology allows for the isolation and enrichment of a common precursor for endothelia, smooth muscle and hematopoietic cells derived from human embryonic stem cells. This precursor has been found to express early endothelial and hematopoietic markers and under specific conditions, it persists in endothelial differentiation, forms vessel like structures with blood cells, and differentiates into smooth muscle cells (SMC). The method and the progenitor cells described may be used for in-vitro vascular engineering, among other things.

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STM-0646: Method of dynamically culturing embryonic stem cells

The present invention is a method for dynamically generating human embryoid bodies (hEBs) that can be used for generating lineage-specific cells and cell lines. All potential applications depend on the availability of a controlled scaleable bioprocess of the differentiated cells. The present invention describes the formation of hEBs in dynamic systems, and discloses simple, culture-specific conditions that allow the formation of hEBs. The initial event participants in the developing hEBs did not change when moved from their conventional culture to dynamic systems, indicating the possibility of simple scaleable cell production in a well-defined dynamic environment for clinical and industrial applications.

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STM-0695: 3D tissue structures using differentiating embryonic stem cells

Human embryonic stem (hES) cells hold promise as an unlimited source of cells for transplantation therapies. The present invention is a method for the control of hES cell proliferation and differentiation into complex, viable 3D tissue constructs. The invention describes the use of biodegradable polymer scaffolds for promoting hES cell growth and differentiation, and for the formation of 3D structures. This approach provides a unique culture system for addressing questions in cell and developmental biology, and provides a potential mechanism for creating viable human tissue structures for therapeutic applications.

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STM-0800: Differentiation of hES cell into osteoblasts, chondrocytes and tendocytes

The present invention describes a method for the efficient derivation of connective tissue progenitors (CTPs) from human embryonic stem (hES) cells. These cells have multilineage developmental potential, yet are committed to connective tissue derivatives. Moreover, the potential of these cells to generate tendon-like structures is also shown. By applying the long-term high-density culture technique to these cells, the researchers successfully assembled cylinder-shaped constructs that contained typical ultrastructure characteristics and biomechanical properties of early tendons.

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STM-0801: Formation, propagation and differentiation of human embryoid bodies

This technology focuses on a platform for production of human embryoid bodies (hEBs) from human embryonic stem (hES) cells. The production takes place in a controlled stirred tank reactor (STR) in a robust scalable process with high efficiency.

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STM-0890: Adult stem cell-derived connective tissue progenitors for tissue engineering

The present invention provides methods for generating and utilization of connective tissue progenitor cells from adult stem cells, successfully overcoming shortcomings of presently known configurations. Adult stem cells differentiate into connective tissue progenitor cells capable of being maintained in a proliferative, non-terminally differentiated state for at least 20 passages in culture, and capable of differentiating into cells of chondrogenic lineage, osteogenic lineage, adipocytic lineage, tendon lineage and ligament lineage. The connective tissue progenitor cells are capable of forming extracellular matrix, mineralized matrix, bone tissue, cartilage tissue, tendon tissue and ligament tissue. Contact us...

STM-0919: Ectodermal precursor cell line derived from hES cells

The present invention provides an isolated stable ectodermal IT1 cell line from human ESC, capable of differentiating into epidermal and corneal cells that could reconstitute in-vitro pluristratified epidermis and cornea. Applications of this invention include use for pre-clinical trials concerning skin and cornea pathologies, production of transplantable epidermis, repair of wounded corneas and design of cellular models for cosmeto-toxicology.

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STM-0956: Embryonic and adult stem cells encapsulation for cell based therapy and cancer

Stem cells are potentially the ultimate source of transplantable cells for many different tissues. A major obstacle in the clinical use of stem cells is their possible immunogenicity. Our technology’s innovative approach is to entrap the cells in capsules made of biocompatible polymers. This approach was specifically designed to take advantage of the immortality of these cells, while avoiding any possible immune response or the formation of teratomas. These capsules protect the cells from the immune system and act as a mini bioreactor, allowing them to secrete the engineered factor or natural therapeutic near sites of interest. Read more...

STM-1148: Pancreatic progenitor enrichment of hES cell culture by GLUT2 sorting

Type I diabetes mellitus is caused by an autoimmune destruction of the insulin-producing cells. The major obstacle in using transplantation for curing the disease is the limited source of insulin-producing cells. The earliest human pancreatic progenitors are marked by the transcription factor pancreatic duodenal homeobox (PDX1). In normal β-cells, PDX-1 transactivates the insulin gene and other genes involved in glucose sensing and metabolism, such as GLUT2 and glucokinase. Several protocols have been tested, in order to increase the PDX1 expressing population in differentiating human embryonic stem (hES) cells or human inducible pluripotent stem cells (iPS), in an attempt to obtain pancreatic progenitors cells which may further develop into insulin producing cells.

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STM-1283: Production of corneal tissue equivalents from human pluripotent stem cells

In severe cases of corneal diseases such as total limbal stem cell deficiency, allo-grafts are obtained from patient’s relatives or from post mortem donors. This approach is commonly used for years. However, shortage of donors and graft rejection are major drawbacks of this approach. Our novel invention is based on the production of corneal cells from human embryonic stem (hES) cells, allowing the production of unlimited amount of corneal epithelia ready to be transplanted into injured eye of patient. Contact us...

STM-1290: Deriving extracellular matrix from hES cells and human iPS cells

The extracellular matrix (ECM) composition affects the cell attachment, migration, proliferation and 3D arrangement. This new invention uses differentiated human embryonic stem (hES) cells or human induced pluripotent stem cells (iPS) to generate ECM for surgical applications. This new invention may be used as a biological a-cellular scaffold with the advantages of homogeneity, availability, bioactivity, biocompatibility and safety for surgical application.

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WAT-0526: Bacterial DNA fingerprint detection

This is a fast and highly accurate system for identifying the presence of bacteria, based on the detection of its DNA sequence in the inspected medium. The technology is capable of identifying bacterial strains and can be easily adaptable to any bacteria. This new technology can be used to automatically detect the presence of bacteria in food and water, as well as in biological and medical samples.

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WAT-0848: Resin-linked oligy-acyl-lysines for the capture and concentration of bacteria

This is a method for the filtration and concentration of bacterial contaminants. Most water, food, and clinical samples usually contain bacteria below detection limits. This innovative technology proposes a system that assembles the bacteria into a larger mass. The system exploits the affinity of microorganisms for peptidomimetic compound oligy-acyl-lysines (OAKs), which were recently developed by the inventors as antimicrobial agents. OAKs are linked to an inert supporting material (resin), resulting in a resin-linked OAK (ROAK) that maintains high binding affinity for microbial cells.

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WAT-1261: Removal of nitrogen and phosphorus species

The industry of fish growth for food is expanding rapidly, requiring novel fish growing systems and technologies. The present invention describes a novel physic-chemical purely methodology for the operation of intensive fish growing units (RAS), with respect to nutrient (N and P species) removal methods. The new technology is economical and reliable method for the removal of nitrogen and phosphorus dissolved species excreted by the fish.

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